Thioflavin T (ThT) has been widely used to investigate amyloid formation since 1989. While
concerns have recently been raised about its use as a probe specific for amyloid, ThT still …

Amyloid proteins cause a number of progressive, degenerative diseases. Among these is
Alzheimer's disease (AD), the etiology of which is linked to the formation of neurotoxic …

In recent years, small protein oligomers have been implicated in the aetiology of a number of
important amyloid diseases, such as type 2 diabetes, Parkinson's disease and Alzheimer's …

Aggregation of the Aβ1–40 peptide is linked to the development of extracellular plaques
characteristic of Alzheimer's disease. While previous studies commonly show the Aβ1–40 is …

Amyloid-like fibrous crystals formed by the peptide KFFEAAAKKFFE have been previously
characterized and provide an ideal model system to examine the importance of specific …

Alloform-specific differences in structural dynamics between amyloid β-protein (Aβ) 40 and
Aβ42 appear to underlie the pathogenesis of Alzheimer's disease. To elucidate these …

The early events in the aggregation of the intrinsically disordered peptide, amyloid-β (A β),
involve transitions from the disordered free energy ground state to assembly-competent …

It is widely accepted that the abnormal self-association of amyloid β-protein (Aβ) is central to
the pathogenesis of Alzheimer's disease, the most common form of dementia. Accumulating …

Mutations in the amyloid β-protein (Aβ) precursor gene cause autosomal dominant
Alzheimer disease in a number of kindreds. In two such kindreds, the English and the Tottori …

A combination of hydrophobic and electrostatic interactions is important in initiating the
aberrant self-assembly process that leads to formation of toxic oligomers and aggregates by …