The prevalence of heart failure is on the rise and imposes a major health threat, in part, due
to the rapidly increased prevalence of overweight and obesity. To this point …

With the rising prevalence of obesity has come an increasing awareness of its impact on
communicable disease. As a consequence of the 2009 H1N1 influenza A virus pandemic …

The discovery of leptin changed the view of adipose tissue from that of a passive vessel that
stores fat to that of a dynamic endocrine organ that actively regulates behaviour and …

More than one-third of the worldwide population is overweight or obese and therefore at risk
of developing type 2 diabetes mellitus. In order to mitigate this pandemic, safer and more …

Despite its central importance in cellular metabolism, many details remain to be determined
regarding subcellular lactate metabolism and its regulation in physiology and disease, as …

Despite all modern advances in medicine, an effective drug treatment of obesity has not
been found yet. Discovery of leptin two decades ago created hopes for treatment of obesity …

Little is known about how interactions of diet, intestinal stem cells (ISCs), and immune cells
affect early-stage intestinal tumorigenesis. We show that a high-fat diet (HFD) reduces the …

Growing evidence implicates the brain in the regulation of both immediate fuel availability
(for example, circulating glucose) and long-term energy stores (that is, adipose tissue mass) …

Bone has recently emerged as a pleiotropic endocrine organ that secretes at least two
hormones, FGF23 and osteocalcin, which regulate kidney function and glucose …

Insulin resistance is a major underlying mechanism for the “metabolic syndrome”, which is
also known as insulin resistance syndrome. Metabolic syndrome is increasing at an …