Revisiting the grammar of Tau aggregation and pathology formation: how new insights from brain pathology are shaping how we study and target Tauopathies

G Limorenko, HA Lashuel - Chemical Society Reviews, 2022 - pubs.rsc.org
Converging evidence continues to point towards Tau aggregation and pathology formation
as central events in the pathogenesis of Alzheimer's disease and other Tauopathies …

Type 2 diabetes mellitus and Alzheimer's disease: shared molecular mechanisms and potential common therapeutic targets

R Hamzé, E Delangre, S Tolu, M Moreau… - International journal of …, 2022 - mdpi.com
The global prevalence of diabetes mellitus and Alzheimer's disease is increasing alarmingly
with the aging of the population. Numerous epidemiological data suggest that there is a …

Alzheimer's disease: updated multi-targets therapeutics are in clinical and in progress

Z Sang, K Wang, J Dong, L Tang - European journal of medicinal chemistry, 2022 - Elsevier
Alzheimer's disease is a chronic and progressive brain neurodegenerative disease affecting
over 30 million people globally. Currently, no effective treatment is available due to multiple …

[HTML][HTML] Signal pathways in the treatment of Alzheimer's disease with traditional Chinese medicine

MR Ding, YJ Qu, B Hu, HM An - Biomedicine & Pharmacotherapy, 2022 - Elsevier
Aim of the review This study aimed to reveal the classical signal pathways and important
potential targets of traditional Chinese medicine (TCM) for treating Alzheimer's disease (AD) …

Glycogen synthase kinase-3 inhibitors: preclinical and clinical focus on CNS-A decade onward

SM Arciniegas Ruiz, H Eldar-Finkelman - Frontiers in molecular …, 2022 - frontiersin.org
The protein kinase, GSK-3, participates in diverse biological processes and is now
recognized a promising drug discovery target in treating multiple pathological conditions …

Multi-targets: An unconventional drug development strategy for Alzheimer's disease

CX Gong, CL Dai, F Liu, K Iqbal - Frontiers in aging neuroscience, 2022 - frontiersin.org
Alzheimer's disease (AD) is a progressive neurodegenerative disorder that eventually leads
to dementia and death of the patient. Despite the enormous amounts of resources and …

Alzheimer's disease and green tea: epigallocatechin-3-gallate as a modulator of inflammation and oxidative stress

V Valverde-Salazar, D Ruiz-Gabarre… - Antioxidants, 2023 - mdpi.com
Alzheimer's disease (AD) is the most common cause of dementia, characterised by a
marked decline of both memory and cognition, along with pathophysiological hallmarks …

Probiotic Bifidobacterium breve MCC1274 Mitigates Alzheimer's Disease-Related Pathologies in Wild-Type Mice

M Abdelhamid, C Zhou, CG Jung, M Michikawa - Nutrients, 2022 - mdpi.com
Probiotics improve brain function, including memory and cognition, via the microbiome–gut–
brain axis. Oral administration of Bifidobacterium breve MCC1274 (B. breve MCC1274) …

Repositioning of anti-diabetic drugs against dementia: insight from molecular perspectives to clinical trials

KEK Mantik, S Kim, B Gu, S Moon, HB Kwak… - International journal of …, 2023 - mdpi.com
Insulin resistance as a hallmark of type 2 DM (T2DM) plays a role in dementia by promoting
pathological lesions or enhancing the vulnerability of the brain. Numerous studies related to …

Potential implications of miRNAs in the pathogenesis, diagnosis, and therapeutics of Alzheimer's disease

L Wang, X Shui, Y Diao, D Chen, Y Zhou… - International Journal of …, 2023 - mdpi.com
Alzheimer's disease (AD) is a complex multifactorial disorder that poses a substantial
burden on patients, caregivers, and society. Considering the increased aging population …