Animal models of cardiovascular disease are key players in the translational medicine
pipeline used to define the conserved genetic and molecular basis of disease. Congenital …

Molecular scissors engineered for site-specific modification of the genome hold great
promise for effective functional analyses of genes, genomes and epigenomes and could …

The most common and aggressive primitive intracranial tumor of the central nervous system
is the glioma. The blood–brain barrier (BBB) has proven to be a significant obstacle to the …

Cancer is characterized by multiple genetic and epigenetic alterations that drive malignant
cell proliferation and confer chemoresistance. The ability to correct or ablate such mutations …

Therapeutic genome editing technology has been widely used as a powerful tool for directly
correcting genetic mutations in target pathological tissues and cells to cure of diseases. The …

Well-characterized antibody reagents play a key role in the reproducibility of research
findings, and inconsistent antibody performance leads to variability in Western blotting and …

Programmed cell death ligand 1 (PD-L1) is a transmembrane protein that is expressed on
tumor cells that suppresses the T cell-mediated immune response. Therapies targeting the …

Neurotrophins (NTs) are members of a neuronal growth factor protein family whose action is
mediated by the tropomyosin receptor kinase (TRK) receptor family receptors and the p75 …

The development of CRISPR-Cas9 technology has revolutionized our ability to edit DNA
and to modulate expression levels of genes of interest, thus providing powerful tools to …

The Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) genome editing
system has been the focus of intense research in the last decade due to its superior ability to …