Since the original description of its efficacy, indomethacin has been used widely for the
pharmacological closure of patent ductus arteriosus (Friedman et al. 1976; Heymann et al …

Infants and children with congenital or acquired heart disease and children with systemic
disease often require pharmacological support of their failing circulation. Catecholamines …

The pharmacokinetics (PK) and pharmacodynamics (PD) of most medications in children
especially neonates, differ from those in adults. Children exhibit different PK and PD from …

The foregoing discussion leads to several general conclusions regarding the use of digoxin
in the pediatric patient. First, pharmacokinetic studies indicate that somewhat higher doses …

Background Digoxin has been associated with reduced interstage mortality for patients with
functional single ventricles with aortic hypoplasia or ductal-dependent systemic circulation …

Inotropic agents are drugs which increase the stroke work of the heart at a given pre-load
and after-load. All of these agents work through a final common pathway involving the …

Use of Inotropic and Chronotropic Agents in Neonates Page 1 Perinatal Pharmacology oogs
s1os1s7 $Q.QQ 1 .2Q Use of lnotropic and Chronotropic Agents in Neonates David]. Driscoll …

Digoxin toxicity remains a common medical problem for both adults and children. In addition
to a vastly improved understanding of the mechanisms for digoxin action on the heart, there …

This article seeks to make clear the basic differences in the treatment of heart failure
between therapeutic maneuvers that are aimed at improving the mechanical loading …

The place of digoxin in the pediatric cardiologist's armamentarium remains uncertain. As an
antiarrhythmic, its use in the Wolff-Parkinson-White syndrome is obsolete, but it remains …