The oxytocin receptor: from intracellular signaling to behavior

B Jurek, ID Neumann - Physiological reviews, 2018 - journals.physiology.org
The many facets of the oxytocin (OXT) system of the brain and periphery elicited nearly
25,000 publications since 1930 (see, as listed in PubMed), which revealed central roles for …

Advances in the field of intranasal oxytocin research: lessons learned and future directions for clinical research

DS Quintana, A Lischke, S Grace, D Scheele… - Molecular …, 2021 - nature.com
Reports on the modulatory role of the neuropeptide oxytocin on social cognition and
behavior have steadily increased over the last two decades, stimulating considerable …

Intranasal oxytocin: myths and delusions

G Leng, M Ludwig - Biological psychiatry, 2016 - Elsevier
Despite widespread reports that intranasal application of oxytocin has a variety of behavioral
effects, very little of the huge amounts applied intranasally appears to reach the …

Vasopressin and oxytocin receptor systems in the brain: sex differences and sex-specific regulation of social behavior

KM Dumais, AH Veenema - Frontiers in neuroendocrinology, 2016 - Elsevier
The neuropeptides vasopressin (VP) and oxytocin (OT) and their receptors in the brain are
involved in the regulation of various social behaviors and have emerged as drug targets for …

The biology of mammalian parenting and its effect on offspring social development

JK Rilling, LJ Young - Science, 2014 - science.org
Parents know the transformative nature of having and caring for a child. Among many
mammals, giving birth leads from an aversion to infant stimuli to irresistible attraction. Here …

Labeled oxytocin administered via the intranasal route reaches the brain in rhesus macaques

MR Lee, TA Shnitko, SW Blue, AV Kaucher… - Nature …, 2020 - nature.com
Oxytocin may have promise as a treatment for neuropsychiatric disorders. Its therapeutic
effect may depend on its ability to enter the brain and bind to the oxytocin receptor. To date …

Kinetics and dose dependency of intranasal oxytocin effects on amygdala reactivity

FB Spengler, J Schultz, D Scheele, M Essel, W Maier… - Biological …, 2017 - Elsevier
Background Current neuroimaging perspectives on a variety of mental disorders emphasize
dysfunction of the amygdala. The neuropeptide oxytocin (OXT), a key mediator in the …

Oxytocin by intranasal and intravenous routes reaches the cerebrospinal fluid in rhesus macaques: determination using a novel oxytocin assay

MR Lee, KB Scheidweiler, XX Diao, F Akhlaghi… - Molecular …, 2018 - nature.com
Oxytocin (OT) is a potential treatment for multiple neuropsychiatric disorders. As OT is a
peptide, delivery by the intranasal (IN) route is the preferred method in clinical studies …

Does oxytocin increase trust in humans? A critical review of research

G Nave, C Camerer… - … on Psychological Science, 2015 - journals.sagepub.com
Behavioral neuroscientists have shown that the neuropeptide oxytocin (OT) plays a key role
in social attachment and affiliation in nonhuman mammals. Inspired by this initial research …

[图书][B] Translational mouse models of autism: advancing toward pharmacological therapeutics

TM Kazdoba, PT Leach, M Yang, JL Silverman… - 2016 - Springer
Animal models provide preclinical tools to investigate the causal role of genetic mutations
and environmental factors in the etiology of autism spectrum disorder (ASD). Knockout and …