Hypoalbuminemia: pathogenesis and clinical significance
PB Soeters, RR Wolfe, A Shenkin - Journal of Parenteral and …, 2019 - Wiley Online Library
Hypoalbuminemia is associated with inflammation. Despite being addressed repeatedly in
the literature, there is still confusion regarding its pathogenesis and clinical significance …
the literature, there is still confusion regarding its pathogenesis and clinical significance …
[HTML][HTML] The effect of pathophysiology on pharmacokinetics in the critically ill patient—concepts appraised by the example of antimicrobial agents
Critically ill patients are at high risk for development of life-threatening infection leading to
sepsis and multiple organ failure. Adequate antimicrobial therapy is pivotal for optimizing the …
sepsis and multiple organ failure. Adequate antimicrobial therapy is pivotal for optimizing the …
Immunopathophysiology of trauma-related acute kidney injury
DAC Messerer, R Halbgebauer, B Nilsson… - Nature Reviews …, 2021 - nature.com
Physical trauma can affect any individual and is globally accountable for more than one in
every ten deaths. Although direct severe kidney trauma is relatively infrequent, extrarenal …
every ten deaths. Although direct severe kidney trauma is relatively infrequent, extrarenal …
Pharmacokinetic issues for antibiotics in the critically ill patient
JA Roberts, J Lipman - Critical care medicine, 2009 - journals.lww.com
Objective: To discuss the altered pharmacokinetic properties of selected antibiotics in
critically ill patients and to develop basic dose adjustment principles for this patient …
critically ill patients and to develop basic dose adjustment principles for this patient …
Value of thoracic computed tomography in the first assessment of severely injured patients with blunt chest trauma: results of a prospective study
A Trupka, C Waydhas, KKJ Hallfeldt… - Journal of Trauma …, 1997 - journals.lww.com
Objective The aim of this prospective study was to evaluate whether early thoracic computed
tomography (TCT) is superior to routine chest x-ray (CXR) in the diagnostic work-up of blunt …
tomography (TCT) is superior to routine chest x-ray (CXR) in the diagnostic work-up of blunt …
Antibacterial dosing in intensive care: pharmacokinetics, degree of disease and pharmacodynamics of sepsis
JA Roberts, J Lipman - Clinical pharmacokinetics, 2006 - Springer
Abstract Treatment of sepsis remains a significant challenge with persisting high mortality
and morbidity. Early and appropriate antibacterial therapy remains an important intervention …
and morbidity. Early and appropriate antibacterial therapy remains an important intervention …
Multiple organ dysfunction syndrome in children
JA Tantaleán, RJ León, AA Santos… - Pediatric critical care …, 2003 - journals.lww.com
Objective Delineation of multiple organ dysfunction syndrome (MODS) is important because
of its frequent occurrence in the pediatric intensive care unit and its association with high …
of its frequent occurrence in the pediatric intensive care unit and its association with high …
A personalised approach to antibiotic pharmacokinetics and pharmacodynamics in critically ill patients
AJ Heffernan, SMS Lim, J Lipman… - Anaesthesia Critical Care & …, 2021 - Elsevier
Critically ill patients admitted to intensive care unit (ICU) with severe infections, or those who
develop nosocomial infections, have poor outcomes with substantial morbidity and mortality …
develop nosocomial infections, have poor outcomes with substantial morbidity and mortality …
[HTML][HTML] Optimization of dosing regimens and dosing in special populations
Abstract Treatment of infectious diseases is becoming increasingly challenging with the
emergence of less-susceptible organisms that are poorly responsive to existing antibiotic …
emergence of less-susceptible organisms that are poorly responsive to existing antibiotic …
Predictive value of microalbuminuria in medical ICU patients: results of a pilot study
O Abid, Q Sun, K Sugimoto, D Mercan, JL Vincent - Chest, 2001 - Elsevier
Study objectives To evaluate the predictive value of microalbuminuria in the development of
acute respiratory failure (ARF) and multiple organ failure (MOF) in ICU patients. Design …
acute respiratory failure (ARF) and multiple organ failure (MOF) in ICU patients. Design …