The ionome is defined as the mineral nutrient and trace element composition of an organism
and represents the inorganic component of cellular and organismal systems. Ionomics, the …

The redox-active metal manganese plays a key role in cellular adaptation to oxidative stress.
As a cofactor for manganese superoxide dismutase or through formation of non …

Background and Aims Hepatocellular carcinoma (HCC) is associated with high malignancy
rates. Recently, a known deacetylase silent information regulator 1 (SIRT1) was discovered …

Ionomics is a high-throughput elemental profiling approach to study the molecular
mechanistic basis underlying mineral nutrient and trace element composition (also known …

All living organisms require nutrient minerals for growth and have developed mechanisms to
acquire, utilize, and store nutrient minerals effectively. In the aqueous cellular environment …

The emerging field of metallomics refers to the entirety of research activities aimed at the
understanding of the molecular mechanisms of metal-dependent life processes. This critical …

All eukaryotic cells contain multiple acidic organelles, and V-ATPases are central players in
organelle acidification. Not only is the structure of V-ATPases highly conserved among …

BACKGROUND: Nearly all processes in living cells are pH dependent, which is why
intracellular pH (pHi) is a tightly regulated physiological parameter in all cellular systems …

Background Acetic acid is a byproduct of Saccharomyces cerevisiae alcoholic fermentation.
Together with high concentrations of ethanol and other toxic metabolites, acetic acid may …

Conclusions In a large cohort of DAA‐treated patients with cirrhotic HCV, GRS was
associated with de novo HCC independently of classical risk factors, including liver disease …