The role of a novel mineralocorticoid receptor antagonist, finerenone, in chronic kidney disease: mechanisms and clinical advances
X Chen, X Li, K Zhang, K Lian, W Zhang… - Clinical and …, 2024 - Springer
Background Chronic kidney disease (CKD) poses a significant health risk in contemporary
society. Current CKD treatments primarily involve renin-angiotensin-aldosterone system …
society. Current CKD treatments primarily involve renin-angiotensin-aldosterone system …
The Pharmacokinetics of the Nonsteroidal Mineralocorticoid Receptor Antagonist Finerenone
R Heinig, T Eissing - Clinical Pharmacokinetics, 2023 - Springer
Finerenone, a selective and nonsteroidal antagonist of the mineralocorticoid receptor, has
received regulatory approval with the indication of cardiorenal protection in patients with …
received regulatory approval with the indication of cardiorenal protection in patients with …
A comparative analysis of colour–emotion associations in 16–88‐year‐old adults from 31 countries
D Jonauskaite, D Epicoco… - British Journal of …, 2024 - Wiley Online Library
As people age, they tend to spend more time indoors, and the colours in their surroundings
may significantly impact their mood and overall well‐being. However, there is a lack of …
may significantly impact their mood and overall well‐being. However, there is a lack of …
Pharmacokinetics and pharmacodynamics of finerenone in patients with chronic kidney disease and type 2 diabetes: Insights based on FIGARO‐DKD and FIDELIO …
T Eissing, SC Goulooze, P van den Berg… - Diabetes, Obesity …, 2024 - Wiley Online Library
Aims To perform dose–exposure–response analyses to determine the effects of finerenone
doses. Materials and Methods Two randomized, double‐blind, placebo‐controlled phase 3 …
doses. Materials and Methods Two randomized, double‐blind, placebo‐controlled phase 3 …
Results from drug–drug interaction studies in vitro and in vivo investigating the inhibitory effect of finerenone on the drug transporters BCRP, OATP1B1, and OATP1B3
R Heinig, R Fricke, S Wertz, J Nagelschmitz… - European Journal of …, 2022 - Springer
Abstract Background and Objectives In vitro and in vivo studies were performed with the
novel, selective, nonsteroidal mineralocorticoid receptor antagonist finerenone to assess the …
novel, selective, nonsteroidal mineralocorticoid receptor antagonist finerenone to assess the …
Nonsteroidal Mineralocorticoid Receptor Antagonist Eliciting Cardiorenal Protection Is a New Option for Patients with Chronic Kidney Disease
W Liu, S Yu - Kidney Diseases, 2023 - karger.com
Abstract Background: Mineralocorticoid receptor antagonists (MRAs) protect cardiorenal
function by robust anti-inflammatory and antifibrotic functions beyond classical functions of …
function by robust anti-inflammatory and antifibrotic functions beyond classical functions of …
Results from phase I studies investigating the dose linearity of finerenone tablets and the influence of food or pH-modifying comedications on its pharmacokinetics in …
R Heinig, J Nagelschmitz, S Loewen - European Journal of Drug …, 2022 - Springer
Abstract Background and Objectives Finerenone is a nonsteroidal mineralocorticoid
receptor antagonist that reduces the risk of adverse kidney and cardiovascular outcomes in …
receptor antagonist that reduces the risk of adverse kidney and cardiovascular outcomes in …
Real-world evidence for steroidal mineralocorticoid receptor antagonists in patients with chronic kidney disease
K Folkerts, A Millier, B Smela, E Olewinska… - Journal of …, 2023 - Springer
Abstract Background Mineralocorticoid receptor antagonists (MRAs) were shown to delay
chronic kidney disease (CKD) progression in patients with hypertension and/or heart failure …
chronic kidney disease (CKD) progression in patients with hypertension and/or heart failure …
Finerenone: a new mineralocorticoid receptor antagonist to beat chronic kidney disease
R Raj - Current Opinion in Nephrology and Hypertension, 2022 - journals.lww.com
The nonsteroidal MRA finerenone could improve renal and cardiac outcomes further in
diabetics with kidney disease when added to renin-angiotensin system inhibitors …
diabetics with kidney disease when added to renin-angiotensin system inhibitors …
Incidence and progression of atrial fibrillation in patients with and without heart failure using mineralocorticoid receptor antagonists: a meta-analysis
T Sampaio Rodrigues, LJ Garcia Quarto… - Clinical Research in …, 2024 - Springer
Abstract Background Mineralocorticoid receptor antagonists (MRAs) have emerged as
potential therapy to target the underlying arrhythmogenic substrate in atrial fibrillation (AF) …
potential therapy to target the underlying arrhythmogenic substrate in atrial fibrillation (AF) …