In the past decade since kisspeptin/neurokinin B/dynorphin (KNDy) cells were first identified
in the mammalian hypothalamus, a plethora of new research has emerged adding insights …

In late 2003, a major breakthrough in our understanding of the mechanisms that govern
reproduction occurred with the identification of the reproductive roles of kisspeptins …

Classic pharmacological studies suggested that endogenous dynorphin-KOR signaling is
important for reproductive neuroendocrine regulation. With the seminal discovery of an …

The anatomy and morphology of gonadotropin‐releasing hormone (GnRH) neurons makes
them both a joy and a challenge to investigate. They are a highly unique population of …

Work during the last decade has led to a novel hypothesis for a question that is half a
century old: how is the secretory activity of GnRH neurons synchronized to produce episodic …

Regulation of Kiss1 transcription is crucial to the development and function of the
reproductive axis. The homeodomain transcription factor, ventral anterior homeobox 1 …

Kisspeptin and γ-amino butyric acid (GABA), synthesized in the central nervous system, are
critical for reproduction. Both are also expressed in peripheral organs/tissues critical to …

Kisspeptin, encoded by Kiss1 gene expressing neurons in the hypothalamus, is a requisite
for fertility and now appears critical in the regulation of energy balance. Kisspeptin neurons …

Female reproductive success requires multifaceted, temporally coordinated hormone
secretion. The circadian timing system is central to this complex neuroendocrine regulation …

Abstract Glucagon-like peptide-1 (GLP-1) regulates reproduction centrally, although, the
neuroanatomical basis of the process is unknown. Therefore, the putative networking of the …