Despite significant improvements in reperfusion strategies, acute coronary syndromes all too
often culminate in a myocardial infarction (MI). The consequent MI can, in turn, lead to …

Background: Human engineered heart tissue (EHT) transplantation represents a potential
regenerative strategy for patients with heart failure and has been successful in preclinical …

In response to myocardial infarction (MI), cardiac macrophages regulate inflammation and
scar formation. We hypothesized that macrophages undergo polarization state changes over …

Cardiovascular disease is the leading cause of death worldwide. Although investment in
drug discovery and development has been sky-rocketing, the number of approved drugs has …

There has been considerable progress in engineering cardiac scaffolds for the treatment of
myocardial infarction (MI). However, it is still challenging to replicate the structural specificity …

In 1993, the National Institutes of Health (NIH) enacted the Revitalization Act to establish
guidelines for inclusion of women and minorities in clinical research. In 2016, the NIH …

Oxidative stress resulting from the accumulation of high levels of reactive oxygen species is
a salient feature of, and a well-recognised pathological factor for, diverse pathologies. One …

Accumulating evidence suggests that autophagy dysfunction plays a critical role in
myocardial ischemia/reperfusion (I/R) injury. However, the underling mechanism of …

Background: CaMKII (Ca2+/calmodulin-dependent kinase II) plays a central role in cardiac
ischemia/reperfusion (I/R) injury—an important therapeutic target for ischemic heart disease …

DNA-dependent protein kinase catalytic subunit (DNA-PKcs) is a novel inducer to promote
mitochondrial apoptosis and suppress tumor growth in a variety of cells although its role in …