Recent studies demonstrated that mitochondrial antioxidant MnSOD that reduces
mitochondrial (mito) reactive oxygen species (ROS) helps maintain an optimal balance …

Autophagy in cardiomyocyte is involved in myocardial ischemia/reperfusion (MI/R) injury.
Caspase recruitment domain-containing protein 9 (CARD9) plays a critical role in …

Ischemic heart disease is the most common cause of lethal ventricular arrhythmias and
sudden cardiac death (SCD). In patients who are at high risk after myocardial infarction …

Sex differences in heart failure development following myocardial infarction (MI) are not fully
understood. We hypothesized that differential MI signaling could explain variations in …

The adaptive immune response is key for cardiac wound healing post-myocardial infarction
(MI) despite low T-cell numbers. We hypothesized that CD8+ T-cells regulate the …

Matrix metalloproteinases (MMPs) and their endogenous inhibitors have been studied in the
myocardium for the past 2 decades. An incomplete knowledge base and experimental …

After myocardial infarction, remodeling of the left ventricle involves a wound-healing
orchestra involving a variety of cell types. In order for wound healing to be optimal …

There is a lack of understanding in the cardiac remodeling field regarding the use of
nonreperfused myocardial infarction (MI) and reperfused MI in animal models of MI. This …

Whereas prior experiments in juvenile pigs had reported infarct size reduction by
intravenous metoprolol early during myocardial ischaemia, two major clinical trials in …

Following acute occlusion of a coronary artery causing myocardial ischemia and
implementing first-line treatment involving rapid reperfusion, a dynamic and balanced …