Approximately 7 million people are affected by acute myocardial infarction (MI) each year,
and despite significant therapeutic and diagnostic advancements, MI remains a leading …

Cardiovascular diseases are the leading cause of death worldwide. Aging and/or metabolic
stress directly impact the cardiovascular system. Over the last few years, the contributions of …

Necroptosis, which is distinct from apoptosis and necrosis, serves a crucial role in ontogeny
and the maintenance of homeostasis. In the last decade, it has been demonstrated that the …

Patients with insulin resistance and type 2 diabetes have poor cardiac outcomes following
myocardial infarction (MI). The mitochondrial uncoupling protein 3 (UCP3) is down …

Enhanced reactive oxygen species (ROS) at the beginning of reperfusion activated signal
transducer and activator of transcription 3 (STAT3) in intermittent hypobaric hypoxia (IHH) …

Sudden myocardial ischaemia causes an acute coronary syndrome. In the case of ST-
elevation myocardial infarction (STEMI), this is usually caused by the acute rupture of …

Acute myocardial infarction (AMI) is a threat to human life and physical health worldwide.
Timely reperfusion is very important to limit infarct size and protect ischemic myocardium …

Why can we still not translate preclinical research to clinical treatments for acute strokes?
Despite> 1000 successful preclinical studies, drugs, and concepts for acute stroke, only two …

Background Gasdermin D (GSDMD) plays an essential role in the pathway of pyroptosis.
However, whether GSDMD participates in myocardial ischaemia/reperfusion injury (MI/RI) …

Microvascular damage is a key pathological change in myocardial ischemia/reperfusion
(I/R) injury. Using a rat model of myocardial I/R, our current study has provided the first …