[HTML][HTML] Microglia in multiple sclerosis: Protectors turn destroyers

VW Yong - Neuron, 2022 - cell.com
Microglia are implicated in all stages of multiple sclerosis (MS). Microglia alterations are
detected by positron emission tomography in people living with MS prior to the formation of …

Mechanism-based criteria to improve therapeutic outcomes in progressive multiple sclerosis

HYF Yong, VW Yong - Nature Reviews Neurology, 2022 - nature.com
In contrast to the multiple disease-modifying therapies that are available for relapsing–
remitting multiple sclerosis (MS), the therapeutic options for progressive MS (PMS) are …

Disease‐modifying therapies and coronavirus disease 2019 severity in multiple sclerosis

MP Sormani, N De Rossi, I Schiavetti… - Annals of …, 2021 - Wiley Online Library
Objective This study was undertaken to assess the impact of immunosuppressive and
immunomodulatory therapies on the severity of coronavirus disease 2019 (COVID‐19) in …

[HTML][HTML] COVID-19 in patients with multiple sclerosis: associations with disease-modifying therapies

AT Reder, D Centonze, ML Naylor, A Nagpal… - CNS drugs, 2021 - Springer
Abstract Background Disease-modifying therapies (DMTs) for multiple sclerosis (MS) target
immunity and have the potential to increase the risk of severe acute respiratory syndrome …

[HTML][HTML] Multiple sclerosis therapies differentially affect SARS-CoV-2 vaccine–induced antibody and T cell immunity and function

JJ Sabatino Jr, K Mittl, WM Rowles, K McPolin… - JCI insight, 2022 - ncbi.nlm.nih.gov
BACKGROUND Vaccine-elicited adaptive immunity is a prerequisite for control of SARS-
CoV-2 infection. Multiple sclerosis (MS) disease-modifying therapies (DMTs) differentially …

[HTML][HTML] T helper cells: the modulators of inflammation in multiple sclerosis

M Kunkl, S Frascolla, C Amormino, E Volpe, L Tuosto - Cells, 2020 - mdpi.com
Multiple sclerosis (MS) is a chronic neurodegenerative disease characterized by the
progressive loss of axonal myelin in several areas of the central nervous system (CNS) that …

Targeting B cells to modify MS, NMOSD, and MOGAD: part 1

J Graf, J Mares, M Barnett, O Aktas… - Neurology …, 2020 - AAN Enterprises
Ocrelizumab, rituximab, ofatumumab, ublituximab, inebilizumab, and evobrutinib are
immunotherapies that target various B cell–related proteins. Most of these treatments have …

[HTML][HTML] Regulatory cells in multiple sclerosis: From blood to brain

L Calahorra, C Camacho-Toledano, MP Serrano-Regal… - Biomedicines, 2022 - mdpi.com
Multiple sclerosis (MS) is a chronic, autoimmune, and neurodegenerative disease of the
central nervous system (CNS) that affects myelin. The etiology of MS is unclear, although a …

[HTML][HTML] Glatiramer acetate immunomodulation: evidence of neuroprotection and cognitive preservation

A Kasindi, DT Fuchs, Y Koronyo, A Rentsendorj… - Cells, 2022 - mdpi.com
Novel, neuroprotective uses of Copaxone (generic name: glatiramer acetate—GA) are being
examined, primarily in neurological conditions involving cognitive decline. GA is a well …

[HTML][HTML] Disease-modifying therapies and SARS-CoV-2 vaccination in multiple sclerosis: an expert consensus

D Centonze, MA Rocca, C Gasperini, L Kappos… - Journal of …, 2021 - Springer
Abstract Coronavirus disease (COVID-19) appeared in December 2019 in the Chinese city
of Wuhan and has quickly become a global pandemic. The disease is caused by the severe …