[HTML][HTML] Defining the risk of SARS-CoV-2 variants on immune protection

MM DeGrace, E Ghedin, MB Frieman, F Krammer… - Nature, 2022 - nature.com
The global emergence of many severe acute respiratory syndrome coronavirus 2 (SARS-
CoV-2) variants jeopardizes the protective antiviral immunity induced after infection or …

[HTML][HTML] Effectiveness of COVID-19 vaccines against SARS-CoV-2 variants of concern: a systematic review and meta-analysis

B Zeng, L Gao, Q Zhou, K Yu, F Sun - BMC medicine, 2022 - Springer
Background It was urgent and necessary to synthesize the evidence for vaccine
effectiveness (VE) against SARS-CoV-2 variants of concern (VOC). We conducted a …

[HTML][HTML] SARS-CoV-2 vaccination induces immunological T cell memory able to cross-recognize variants from Alpha to Omicron

A Tarke, CH Coelho, Z Zhang, JM Dan, ED Yu… - Cell, 2022 - cell.com
We address whether T cell responses induced by different vaccine platforms (mRNA-1273,
BNT162b2, Ad26. COV2. S, and NVX-CoV2373) cross-recognize early SARS-CoV-2 …

Safety and efficacy of NVX-CoV2373 Covid-19 vaccine

PT Heath, EP Galiza, DN Baxter, M Boffito… - … England Journal of …, 2021 - Mass Medical Soc
Background Early clinical data from studies of the NVX-CoV2373 vaccine (Novavax), a
recombinant nanoparticle vaccine against severe acute respiratory syndrome coronavirus 2 …

[HTML][HTML] Emerging variants of SARS-CoV-2 and novel therapeutics against coronavirus (COVID-19)

A Aleem, AS Ab, AK Slenker - 2021 - europepmc.org
Objectives: Describe the clinical manifestations, including extrapulmonary manifestations of
COVID-19. Outline the latest treatments available in the management of COVID-19 …

Public health impact of covid-19 vaccines in the US: observational study

AB Suthar, J Wang, V Seffren, RE Wiegand, S Griffing… - Bmj, 2022 - bmj.com
Objective To evaluate the impact of vaccine scale-up on population level covid-19 mortality
and incidence in the United States. Design Observational study. Setting US county level …

[HTML][HTML] Accelerated COVID-19 vaccine development: milestones, lessons, and prospects

K Bok, S Sitar, BS Graham, JR Mascola - Immunity, 2021 - cell.com
The development of effective vaccines to combat infectious diseases is a complex multi-year
and multi-stakeholder process. To accelerate the development of vaccines for coronavirus …

[HTML][HTML] Learning the protein language: Evolution, structure, and function

T Bepler, B Berger - Cell systems, 2021 - cell.com
Language models have recently emerged as a powerful machine-learning approach for
distilling information from massive protein sequence databases. From readily available …

Multisystem inflammatory syndrome in children—initial therapy and outcomes

MBF Son, N Murray, K Friedman… - … England Journal of …, 2021 - Mass Medical Soc
Background The assessment of real-world effectiveness of immunomodulatory medications
for multisystem inflammatory syndrome in children (MIS-C) may guide therapy. Methods We …

Confronting the delta variant of SARS-CoV-2, summer 2021

C Del Rio, PN Malani, SB Omer - Jama, 2021 - jamanetwork.com
Availability of safe and highly effective SARS-CoV-2 vaccines increased the possibility of
durable control of COVID-19bothintheUSandworldwide. Afterinitialchallenges in vaccine …