G-protein-coupled receptors (GPCRs) are the largest family of cell surface signaling
receptors known to play a crucial role in various physiological functions, including tumor …

The extracellular matrix (ECM) is a complex network of extracellular-secreted
macromolecules, such as collagen, enzymes and glycoproteins, whose main functions deal …

This review encompasses the most important advances in liver functions and hepatotoxicity
and analyzes which mechanisms can be studied in vitro. In a complex architecture of nested …

Aberrant Wnt signaling can drive cancer development. In many cancer types, the genetic
basis of Wnt pathway activation remains incompletely understood. Here, we report recurrent …

Wnt proteins are a family of secreted proteins that regulate many aspects of cell growth,
differentiation, function, and death. Considerable progress has been made in our …

G protein-coupled receptors (GPCRs) belong to a superfamily of cell surface signalling
proteins that have a pivotal role in many physiological functions and in multiple diseases …

Deciphering what governs inflammation and its effects on tissues is vital for understanding
many pathologies. The recent discovery that glycogen synthase kinase-3 (GSK3) promotes …

Wnt signaling regulates embryonic pattern formation and morphogenesis of most organs.
Aberrations of regulation of Wnt signaling may lead to cancer. Here, we have used …

Human mesenchymal stem cell (MSC)-conditioned medium (CM) was previously reported to
affect the biology of tumor cells; however, the precise mechanisms remain unclear. Here, we …

Glycogen synthase kinase 3β (GSK3β), a multifunctional serine/threonine kinase found in all
eukaryotes, had been initially identified as a key regulator of insulin-dependent glycogen …