The breadth of structure and function displayed by the molecules of biology is remarkable.
Considering that there are only three major biopolymer backbones (proteins, ribonucleic …

Locked nucleic acid (LNA) is a nucleic acid analogue that displays unprecedented
hybridization affinity towards complementary DNA and RNA. Structural studies have shown …

This review focuses on the potentials and perspectives of Locked Nucleic Acid (LNA)-based
oligonucleotides as therapeutic candidates. It briefly outlines various oligonucleotide-based …

RNA interference technology has become a powerful laboratory tool to study gene function.
Small interfering RNAs (siRNAs) have provided unprecedented opportunities for the …

LNA is a bicyclic nucleic acid analogue that contains one or more 2 '-O, 4 '-C methylene
linkage (s), which effectively locks the furanose ring in a C3 '-endo conformation. We report …

Locked nucleic acids (LNAs) are conformationally restricted RNA nucleotides. Their
increased thermal stability and selectivity toward their complements make them well-suited …

Ribofuranose sugar conformation plays an important role in the structure and dynamics of
functional nucleic acids such as siRNAs, AONs, aptamers, miRNAs, etc. To improve their …

Over the last century, medicine has come out of the" black bag" and emerged as one of the
most dynamic and advanced fields of development in science and technology. Today …

Small interfering RNAs (siRNAs) are short, double-stranded RNAs that use the endogenous
RNAi pathway to mediate gene silencing. Phosphorylation facilitates loading of a siRNA into …

The remarkable binding properties of LNA (Locked Nucleic Acid) and α-L-LNA (the α-L-ribo
configured diastereoisomer of LNA) are summarized, and hybridization results for LNA/2 …