Cellular activation pathways and interaction networks in vascularized composite allotransplantation

L Knoedler, S Knoedler, AC Panayi, CAA Lee… - Frontiers in …, 2023 - frontiersin.org
Vascularized composite allotransplantation (VCA) is an evolving field of reconstructive
surgery that has revolutionized the treatment of patients with devastating injuries, including …

Composite tissue allotransplantation: opportunities and challenges

J Iske, Y Nian, R Maenosono, M Maurer… - Cellular & molecular …, 2019 - nature.com
Vascularized composite allotransplants (VCAs) have unique properties because of diverse
tissue components transplanted en mass as a single unit. In addition to surgery, this type of …

Recent developments in extracellular matrix remodeling for fat grafting

X Bi, Y Li, Z Dong, J Zhao, W Wu, J Zou… - Frontiers in Cell and …, 2021 - frontiersin.org
Remodeling of the extracellular matrix (ECM), which provides structural and biochemical
support for surrounding cells, is vital for adipose tissue regeneration after autologous fat …

Methods of ex vivo analysis of tissue status in vascularized composite allografts

C Ton, S Salehi, S Abasi, JR Aggas, R Liu… - Journal of translational …, 2023 - Springer
Vascularized composite allotransplantation can improve quality of life and restore
functionality. However, the complex tissue composition of vascularized composite allografts …

Genetic Modification of Limbs Using Ex Vivo Machine Perfusion

E Valdivia, T Rother, Y Yuzefovych, F Hack… - Human Gene …, 2022 - liebertpub.com
Genetic engineering is a promising tool to repair genetic disorders, improve graft function, or
reduce immune responses toward allografts. Ex vivo organ perfusion systems have the …

The disturbed function of neutrophils at the early stage of fat grafting impairs long-term fat graft retention

K Liu, J Cai, H Li, J Feng, C Feng… - Plastic and Reconstructive …, 2018 - journals.lww.com
Background: Fat grafting is a popular soft-tissue filler method; however, the mechanism of its
survival and regeneration is still not fully understood. Neutrophils are the frontier …

Polyethylene glycol‐fusion repair of sciatic allografts in female rats achieves immunotolerance via attenuated innate and adaptive responses

TA Smith, CL Ghergherehchi, M Mikesh… - Journal of …, 2020 - Wiley Online Library
Ablation/segmental loss peripheral nerve injuries (PNIs) exhibit poor functional recovery due
to slow and inaccurate outgrowth of regenerating axons. Viable peripheral nerve allografts …

Preservation solutions for attenuation of ischemia–reperfusion injury in vascularized composite allotransplantation

S Datta, AM Fitzpatrick, S Haykal - SAGE Open Medicine, 2021 - journals.sagepub.com
Vascularized composite allotransplantation represents the final level of the reconstructive
ladder, offering treatment options for severe tissue loss and functional deficiencies …

A chronic rejection model and potential biomarkers for vascularized composite allotransplantation

F Puscz, M Dadras, A Dermietzel, F Jacobsen… - PLoS …, 2020 - journals.plos.org
Background Chronic rejection remains the Achilles heel in vascularized composite
allotransplantation. Animal models to specifically study chronic rejection in vascularized …

Vascularized composite allotransplantation versus solid organ transplantation: innate-adaptive immune interphase

K Kadono, M Gruszynski, K Azari… - Current opinion in …, 2019 - journals.lww.com
Vascularized composite allotransplantation versus solid orga... : Current Opinion in Organ
Transplantation Vascularized composite allotransplantation versus solid organ …