[HTML][HTML] Molecular pathways of major depressive disorder converge on the synapse

GR Fries, VA Saldana, J Finnstein, T Rein - Molecular psychiatry, 2023 - nature.com
Major depressive disorder (MDD) is a psychiatric disease of still poorly understood
molecular etiology. Extensive studies at different molecular levels point to a high complexity …

[HTML][HTML] Recognizing the role of the vagus nerve in depression from microbiota-gut brain axis

C Tan, Q Yan, Y Ma, J Fang, Y Yang - Frontiers in Neurology, 2022 - frontiersin.org
Depression is a worldwide disease causing severe disability, morbidity, and mortality.
Despite abundant studies, the precise mechanisms underlying the pathophysiology of …

Neurobiology and systems biology of stress resilience

R Kalisch, SJ Russo, MB Müller - Physiological Reviews, 2024 - journals.physiology.org
Stress resilience is the phenomenon that some people maintain their mental health despite
exposure to adversity or show only temporary impairments followed by quick recovery …

The neurobiology of stress: Vulnerability, resilience, and major depression

H Akil, EJ Nestler - Proceedings of the National Academy of …, 2023 - National Acad Sciences
Over the past few years, the perceived level of psychological stress has risen dramatically
across the globe due to a combination of events including the long-lasting Covid-19 …

[HTML][HTML] The pathobiological basis of depression in Parkinson disease: challenges and outlooks

KA Jellinger - Journal of neural transmission, 2022 - Springer
Depression, with an estimated prevalence of about 40% is a most common neuropsychiatric
disorder in Parkinson disease (PD), with a negative impact on quality of life, cognitive …

[HTML][HTML] Post-stroke environmental enrichment improves neurogenesis and cognitive function and reduces the generation of aberrant neurons in the mouse …

F Woitke, A Blank, AL Fleischer, S Zhang… - Cells, 2023 - mdpi.com
Ischemic lesions stimulate adult neurogenesis in the dentate gyrus, however, this is not
associated with better cognitive function. Furthermore, increased neurogenesis is …

Plasticity of synapses and reward circuit function in the genesis and treatment of depression

SM Thompson - Neuropsychopharmacology, 2023 - nature.com
What changes in brain function cause the debilitating symptoms of depression? Can we use
the answers to this question to invent more effective, faster acting antidepressant drug …

[HTML][HTML] Sinisan alleviates depression-like behaviors by regulating mitochondrial function and synaptic plasticity in maternal separation rats

D Deng, Y Cui, S Gan, Z Xie, S Cui, K Cao, S Wang… - Phytomedicine, 2022 - Elsevier
Background Sinisan (SNS) consists of four kinds of herbs, which is the core of
antidepressant prescription widely used in traditional Chinese medicine clinic treatment for …

[HTML][HTML] Shared biological mechanisms of depression and obesity: focus on adipokines and lipokines

X Fu, Y Wang, F Zhao, R Cui, W Xie, Q Liu… - Aging (Albany …, 2023 - ncbi.nlm.nih.gov
Depression and obesity are both common disorders currently affecting public health,
frequently occurring simultaneously within individuals, and the relationship between these …

Neural stem cell metabolism revisited: a critical role for mitochondria

V Scandella, F Petrelli, DL Moore, SMG Braun… - Trends in Endocrinology …, 2023 - cell.com
Metabolism has emerged as a key regulator of stem cell behavior. Mitochondria are crucial
metabolic organelles that are important for differentiated cells, yet considered less so for …