Isolation and characterization of N‐(2‐Hydroxyethyl)hexadecanamide from Colletotrichum gloeosporioides with apoptosis‐inducing potential in breast cancer cells

N Rai, P Gupta, A Verma, SK Singh, V Gautam - BioFactors, 2023 - Wiley Online Library
Endophytic fungi are a well‐established reservoir of bioactive compounds that are
pharmaceutically valuable and therefore, contribute significantly to the biomedical field. The …

Can some marine-derived fungal metabolites become actual anticancer agents?

NGM Gomes, F Lefranc, A Kijjoa, R Kiss - Marine Drugs, 2015 - mdpi.com
Marine fungi are known to produce structurally unique secondary metabolites, and more
than 1000 marine fungal-derived metabolites have already been reported. Despite the …

Metabolites from marine invertebrates and their symbiotic microorganisms: Molecular diversity discovery, mining, and application

L Liu, YY Zheng, CL Shao, CY Wang - Marine Life Science & Technology, 2019 - Springer
Metabolites from marine organisms have proven to be a rich source for the discovery of
multiple potent bioactive molecules with diverse structures. In recent years, we initiated a …

Kinase inhibitors of marine origin

SB Bharate, SD Sawant, PP Singh… - Chemical …, 2013 - ACS Publications
The ocean occupies three-fourths of the Earth's surface and hosts approximately 80% of all
living species. In fact, some areas of the sea such as coral reefs possess a biodiversity …

Anthraquinone: a promising scaffold for the discovery and development of therapeutic agents in cancer therapy

S Siddamurthi, G Gutti, S Jana, A Kumar… - Future medicinal …, 2020 - Taylor & Francis
Cancer, characterized by uncontrolled malignant neoplasm, is a leading cause of death in
both advanced and emerging countries. Although, ample drugs are accessible in the market …

Resveratrol enhances antitumor activity of TRAIL in prostate cancer xenografts through activation of FOXO transcription factor

S Ganapathy, Q Chen, KP Singh, S Shankar… - PloS one, 2010 - journals.plos.org
Background Resveratrol (3, 4′, 5 tri-hydroxystilbene), a naturally occurring polyphenol,
exhibits anti-inflammatory, antioxidant, cardioprotective and antitumor activities. We have …

[HTML][HTML] Marine compounds targeting the PI3K/Akt signaling pathway in cancer therapy

J Wei, Z Gou, Y Wen, Q Luo, Z Huang - Biomedicine & Pharmacotherapy, 2020 - Elsevier
Cancer is a disease characterized by overproliferation, including that due to transformation,
apoptosis disorders, proliferation, invasion, angiogenesis and metastasis, and is one of the …

Antibiotic fidaxomicin is an RdRp inhibitor as a potential new therapeutic agent against Zika virus

J Yuan, J Yu, Y Huang, Z He, J Luo, Y Wu, Y Zheng… - BMC medicine, 2020 - Springer
Background Zika virus (ZIKV) infection is a global health problem, and its complications,
including congenital Zika syndrome and Guillain-Barré syndrome, constitute a continued …

An assessment of natural product discovery from marine (sensu strictu) and marine-derived fungi

DP Overy, P Bayman, RG Kerr, GF Bills - Mycology, 2014 - Taylor & Francis
The natural products community has been investigating secondary metabolites from marine
fungi for several decades, but when one attempts to search for validated reports of new …

FoxO proteins: regulation and molecular targets in liver cancer

S Carbajo-Pescador, JL Mauriz… - Current medicinal …, 2014 - ingentaconnect.com
Human forkhead box class O (FoxO) transcription factors, activated in response to a wide
range of external stimuli, like growth factors, insulin, nutrient levels and oxidative stress, are …