IL-6 is usually described as a pleiotropic cytokine produced in response to tissue injury or
infection. As a pro-inflammatory cytokine, IL-6 activates innate and adaptative immune …

The endoplasmic reticulum (ER) and mitochondria are interconnected intracellular
organelles with vital roles in the regulation of cell signaling and function. While the ER …

Mitochondria are the key organelles for sensing oxygen, which is consumed by oxidative
phosphorylation to generate ATP. Lysosomes contain hydrolytic enzymes that degrade …

Pulmonary hypertension (PH) is a heterogeneous and fatal disease of the lung vasculature,
where metabolic and mitochondrial dysfunction may drive pathogenesis. Similar to the …

Mitochondrial dynamics, including fission and fusion processes, are essential for heart
health. Mitochondria, the powerhouses of cells, maintain their integrity through continuous …

Vascular smooth muscle cell (VSMC) proliferation and migration are critical events that
contribute to the pathogenesis of vascular diseases such as atherosclerosis, restenosis, and …

Background Previous studies suggested that mdivi-1 (mitochondrial division inhibitor), a
putative inhibitor of dynamin-related protein (DRP1), decreased cancer cell proliferation …

The heart is dependent on ATP production in mitochondria, which is closely associated with
cardiovascular disease because of the oxidative stress produced by mitochondria …

Cardiovascular disease (CVD) is a group of systemic disorders threatening human health
with complex pathogenesis, among which mitochondrial energy metabolism reprogramming …

Secreted exosomes are bioactive particles that elicit profound responses in target cells.
Using targeted metabolomics and global microarray analysis, we identified a role of …