Chronic wounds

V Falanga, RR Isseroff, AM Soulika… - Nature Reviews …, 2022 - nature.com
Chronic wounds are characterized by their inability to heal within an expected time frame
and have emerged as an increasingly important clinical problem over the past several …

Dopamine, immunity, and disease

B Channer, SM Matt, EA Nickoloff-Bybel, V Pappa… - Pharmacological …, 2023 - ASPET
The neurotransmitter dopamine is a key factor in central nervous system (CNS) function,
regulating many processes including reward, movement, and cognition. Dopamine also …

Enhancement strategies for transdermal drug delivery systems: Current trends and applications

D Ramadon, MTC McCrudden, AJ Courtenay… - Drug delivery and …, 2021 - Springer
Transdermal drug delivery systems have become an intriguing research topic in
pharmaceutical technology area and one of the most frequently developed pharmaceutical …

The role of the immune microenvironment in bone, cartilage, and soft tissue regeneration: from mechanism to therapeutic opportunity

Y Xiong, BB Mi, Z Lin, YQ Hu, L Yu, KK Zha… - Military Medical …, 2022 - Springer
Bone, cartilage, and soft tissue regeneration is a complex spatiotemporal process recruiting
a variety of cell types, whose activity and interplay must be precisely mediated for effective …

Neuroendocrine signaling in the skin with a special focus on the epidermal neuropeptides

AT Slominski, RM Slominski… - … of Physiology-Cell …, 2022 - journals.physiology.org
The skin, which is comprised of the epidermis, dermis, and subcutaneous tissue, is the
largest organ in the human body and it plays a crucial role in the regulation of the body's …

Chronic inflammation in non-healing skin wounds and promising natural bioactive compounds treatment

P Schilrreff, U Alexiev - International journal of molecular sciences, 2022 - mdpi.com
Chronic inflammation is one of the hallmarks of chronic wounds and is tightly coupled to
immune regulation. The dysregulation of the immune system leads to continuing …

[HTML][HTML] Cytokinocytes: the diverse contribution of keratinocytes to immune responses in skin

Y Jiang, LC Tsoi, AC Billi, NL Ward, PW Harms… - JCI insight, 2020 - ncbi.nlm.nih.gov
The skin serves as the primary interface between our body and the external environment
and acts as a barrier against entry of physical agents, chemicals, and microbes …

[HTML][HTML] Protective role of melatonin and its metabolites in skin aging

G Bocheva, RM Slominski, Z Janjetovic, TK Kim… - International journal of …, 2022 - mdpi.com
The skin, being the largest organ in the human body, is exposed to the environment and
suffers from both intrinsic and extrinsic aging factors. The skin aging process is …

[HTML][HTML] Macrophages as a therapeutic target to promote diabetic wound healing

M Sharifiaghdam, E Shaabani, R Faridi-Majidi… - Molecular Therapy, 2022 - cell.com
It is well‏‏ established that macrophages are key regulators of wound healing, displaying
impressive plasticity and an evolving phenotype, from an aggressive pro-inflammatory or" …

Deep-learning enabled active biomimetic multifunctional hydrogel electronic skin

K Tao, J Yu, J Zhang, A Bao, H Hu, T Ye, Q Ding… - ACS …, 2023 - ACS Publications
There is huge demand for recreating human skin with the functions of epidermis and dermis
for interactions with the physical world. Herein, a biomimetic, ultrasensitive, and …