The glymphatic system is a unique pathway that utilises end-feet Aquaporin 4 (AQP4)
channels within perivascular astrocytes, which is believed to cause cerebrospinal fluid …

The clearance function is essential for maintaining brain tissue homeostasis, and the
glymphatic system is the main pathway for removing brain interstitial solutes. Aquaporin-4 …

The glymphatic system is a fluid transport network of cerebrospinal fluid (CSF) entering the
brain along arterial perivascular spaces, exchanging with interstitial fluid (ISF), ultimately …

Background: Stroke stimulates reactive astrogliosis, aquaporin 4 (AQP4) depolarization and
neuroinflammation. Preconditioned extracellular vesicles (EVs) from microglia exposed to …

Purpose Brain glymphatic dysfunction is involved in the pathologic process of acute
ischemic stroke (IS). The relationship between brain glymphatic activity and dysfunction in …

Post-stroke acute inhibition of aquaporin 4 (AQP4) is known to exacerbate inflammation and
apoptosis, yet the underlying mechanisms are not fully understood. The objective of this …

Post-stroke depression (PSD) is a frequent and disabling complication of stroke that affects
up to one-third of stroke survivors. The pathophysiology of PSD involves multiple …

Dysfunction of the aquaporin‐4 (AQP4)‐dependent glymphatic waste clearance pathway
has recently been implicated in the pathogenesis of several neurodegenerative diseases …

Social communication and interaction deficits, memory impairment, and anxiety-like
behavior are characterized in many people identified with autism spectrum disorder (ASD) …

The discovery of the glymphatic system has revolutionized our understanding of
cerebrospinal fluid (CSF) circulation and interstitial waste clearance in the brain. This …