Antimicrobials are among the most important and commonly prescribed drugs in the
management of critically ill patients and beta-lactams are the most common antibiotic class …

Therapeutic drug monitoring (TDM) opens the door to personalized medicine, yet it is
infrequently applied to β‐lactam antibiotics, one of the most commonly prescribed drug …

There is evidence that certain infections may induce obesity. Obese persons may also have
more severe infections and have compromised response to therapies. The objective of this …

Physiologic alterations seen in obesity commonly impact the pharmacokinetics (PK) and
pharmacodynamics (PD) of antibiotics and may result in suboptimal dosing in this …

Purpose There is variability in the pharmacokinetics (PK) of antibiotics (AB) in critically ill
patients. Therapeutic drug monitoring (TDM) could overcome this variability and increase PK …

Infections occur frequently in critically ill patients and their management can be challenging
for various reasons, including delayed diagnosis, difficulties identifying causative …

Purpose Risk factors for β-lactam antibiotic underdosing in critically ill patients have not
been described in large-scale studies. The objective of this study was to describe …

What is known and objective Meropenem, a carbapenem antibiotic, is widely prescribed for
the treatment of life‐threatening infections. The main parameter associated with its …

The increased prevalence of obesity presents challenges for clinicians aiming to provide
optimised antimicrobial dosing in the intensive care unit. Obesity is likely to exacerbate the …

Background Healthcare-associated infections involving Gram-negative bacteria (GNB) with
difficult-to-treat resistance (DTR) phenotype are associated with impaired patient-centered …