The translocator protein 18 kDa (TSPO) is localized in the outer mitochondrial membrane of
many cell types and its expression is found to be up-regulated under various pathological …

Specific ligands of the peripheral benzodiazepine receptor (PBR) are known to induce
apoptosis and cell cycle arrest in oesophageal cancer cells. However, the underlying …

Since the discovery of antitumor activity of cisplatin in the late 60's, the development of metal-
based drugs has had an enormous burst with the aim of to increase the anti-cancer activity …

Some synthetic ligands of the peripheral-type benzodiazepine receptor (PBR), an 18kDa
protein of the outer mitochondrial membrane, are cytotoxic for several tumor cell lines and …

Translocator protein (TSPO), previously known as the peripheral-type benzodiazepine
receptor, is a ubiquitous drug-and cholesterol-binding protein primarily found in the outer …

Bz-423 is a novel proapoptotic 1, 4-benzodiazepine that induces cell death via a superoxide
signal. Previous work has shown that Bz-423 ameliorates disease in animal models of …

Ligands addressed to the mitochondrial Translocator Protein (TSPO) have been suggested
as cell death/life and steroidogenesis modulators. Thus, TSPO ligands have been proposed …

The effects of PK11195, a high‐affinity peripheral benzodiazepine receptor (PBR) ligand, on
protein phosphorylation in isolated purified rat brain mitochondria were investigated. The …

There is an increasing accumulation of data on the exceptional importance of mitochondria
in the occurrence and treatment of cancer, and in all lines of evidence for such participation …

AIM: To investigate the antineoplastic potency of the novel insulin-like growth factor 1
receptor (IGF-1R) tyrosine kinase inhibitor (TKI) NVP-AEW541 in cell lines and primary cell …