The conversion of guanosine triphosphate (GTP) to guanosine diphosphate (GDP) and
inorganic phosphate (P i) by guanine nucleotide binding proteins (GNBPs) is a fundamental …

The selective transfer of material between membrane-delimited organelles is mediated by
protein-coated vesicles. In many instances, formation of membrane trafficking intermediates …

ARNO is a soluble guanine nucleotide exchange factor (GEF) for the Arf family of GTPases.
Although in biochemical assays ARNO prefers Arf1 over Arf6 as a substrate, its localization …

The ADP-ribosylation factor (Arf) GTPases and their regulatory proteins are implicated in
cancer progression. NAV-2729 was previously identified as a specific inhibitor of Arf6 that …

Adenosine diphosphate–ribosylation factor (Arf) guanosine triphosphatase–activating
proteins (GAPs) are enzymes that need to bind to membranes to catalyze the hydrolysis of …

Summary Background Arf GAPs are multidomain proteins that function in membrane traffic
by inactivating the GTP binding protein Arf1. Numerous Arf GAPs contain a BAR domain, a …

The present study aimed to analyze the expression levels of adenosine diphosphate
ribosylation factor guanylate kinase 1 (ASAP1) and focal adhesion kinase (FAK) in gastric …

ADP ribosylation factors (Arf) regulate membrane trafficking at multiple intracellular sites by
recruiting coat proteins to membranes. The site-specific regulation of Arf is thought to be …

The organelle paralogy hypothesis is one model for the acquisition of nonendosymbiotic
organelles, generated from molecular evolutionary analyses of proteins encoding specificity …

Brag2, a Sec7 domain (sec7d)-containing guanine nucleotide exchange factor, regulates
cell adhesion and tumor cell invasion. Brag2 catalyzes nucleotide exchange, converting Arf …