Abstract Objective: Hpr6 (heme-1 domain protein/human progesterone receptor) is one of a
family of proteins that are implicated in progesterone metabolism, resistance to genotoxic …

During pregnancy, uterine quiescence is maintained by increased progesterone receptor
(PR) activity, but labor is facilitated by a series of events that impair PR function. Previously …

Interactions between steroid hormone receptors and signal transducer and activator of
transcription (Stat)-mediated signaling pathways have already been described. In the …

Background: Reestablishment of metastasis suppressor gene expression may constitute a
therapeutic strategy for high-risk breast cancer patients. We previously showed that …

Accumulating evidence indicates that progestins are involved in controlling mammary gland
tumorigenesis. Here, we assessed the molecular mechanisms of progestin action in breast …

Temporin-1CEa is an antimicrobial peptide isolated from the skin secretions of the Chinese
brown frog (Rana chensinensis). We have previously reported the rapid and broad-spectrum …

Background: Breast cancer is the most common cancer in women worldwide and although
mortality (129 000/year) stagnates, incidence (370 000/year) is increasing. In addition to …

Background Breast cancer cells invading the connective tissues outside the mammary
lobule or duct immerse in a reservoir of extracellular matrix (ECM) that is structurally and …

Oncogenic properties, along with the metabolic reprogramming necessary for tumour growth
and motility, are acquired by cancer cells. Thus, tumour metabolism is becoming a target for …

The mitochondrial gatekeeper voltage-dependent anion channel 1 (VDAC1) controls
metabolic and energy cross-talk between mitochondria and the rest of the cell and is …