The panallergen concept encompasses families of related proteins, which are involved in
general vital processes and thus, widely distributed throughout nature. Plant panallergens …

The structure determination of major allergens is a prerequisite for analyzing surface
exposed areas of the allergen and for mapping conformational epitopes. These may be …

Cycads represent one of the most ancient lineages of living seed plants. Identifying genomic
features uniquely shared by cycads and other extant seed plants, but not non-seed …

Type I hypersensitivity (allergic reaction) is an unsuitable or overreactive immune response
to an allergen due to cross-link immunoglobulin E (IgE) antibodies bound to its high-affinity …

Among other legal regulations, the Note for Guidance on Allergen Products
CPMP/BWP/243/96 released by the European Medicines Agency provides regulatory …

Background: The release of the aeroallergen Bet v 1 from pollen is a major determinant in
the etiology of allergic airway disease due to birch pollen. Objective: We determined the …

OBJECTIVE: To provide guidelines for the rational formulation of allergen immunotherapy
extracts based on knowledge of pollen allergen and epitope cross-reactivity. DATA …

Abstract The Miro GTPases represent an unusual subgroup of the Ras superfamily and have
recently emerged as important mediators of mitochondrial dynamics and for maintaining …

Understanding the function of a protein requires not only knowledge of its tertiary structure
but also an understanding of its conformational dynamics. Nuclear magnetic resonance …

Antibodies classically bind antigens via their complementarity-determining regions, but an
alternative mode of interaction involving V-domain framework regions has been observed …