The success of nucleoside reverse transcriptase inhibitors (NRTIs) in treating HIV‐1
infection and reducing mother‐to‐child transmission of the virus during pregnancy is …

The search for a cure for AIDS has resulted in the discovery of treatment effects of three
types of drugs: nucleoside reverse transcriptase inhibitors (NRTIs), protease inhibitors, and …

Azido‐3′‐deoxythymidine (AZT), a nucleoside analogue used for the treatment of acquired
immunodeficiency syndrome (AIDS), induced a significant dose‐related increase in the …

Mother-to-child transmission of the human immunodeficiency virus (HIV) is reduced by
perinatal treatment with the antiretroviral nucleoside analogue 3′-azido-3 …

Several systemic and cellular markers of 3′‐azido‐3′‐dideoxythymidine (AZT)
metabolism and AZT incorporation into nuclear DNA were measured in cord blood from …

Previous studies have compared age‐related differences in total mutagenic burden in mice
of differing age (preweanling, weanling, or young adult) after single intraperitoneal (ip) …

The TK6 lymphoblastoid cell line is known to be mismatch repair (MMR) and p53 proficient.
Deficiency in MMR results in a mutator phenotype characterized by microsatellite instability …

In the present study we focused our attention on the effect of AZT, at pharmacological and
suprapharmacological concentrations, on some apoptosis-related key events and …

Background Health concerns for HIV-infected persons on antiretroviral therapy (ART) have
moved from morbidity to the challenges of long-term ART. We investigated the effect of …

Antiretroviral therapies based on nucleoside reverse transcriptase inhibitors, like zidovudine
(3′‐azido‐3′‐deoxythymidine; AZT) and didanosine (2′, 3′‐dideoxyinosine; ddI) …