Endophytic fungi: An effective alternative source of plant-derived bioactive compounds for pharmacological studies

J Wen, SK Okyere, S Wang, J Wang, L Xie, Y Ran… - Journal of Fungi, 2022 - mdpi.com
Plant-associated fungi (endophytic fungi) are a biodiversity-rich group of microorganisms
that are normally found asymptomatically within plant tissues or in the intercellular spaces …

Therapeutic compounds from medicinal plant endophytes: molecular and metabolic adaptations

G Sharma, S Agarwal, K Verma… - Journal of Applied …, 2023 - academic.oup.com
During the last few decades, endophytes have attracted increased attention due to their
ability to produce a plethora of bioactive secondary metabolites. These compounds not only …

Recent findings in azaphilone pigments

LPS Pimenta, DC Gomes, PG Cardoso, JA Takahashi - Journal of Fungi, 2021 - mdpi.com
Filamentous fungi are known to biosynthesize an extraordinary range of azaphilones
pigments with structural diversity and advantages over vegetal-derived colored natural …

Aspergillus niger as a Secondary Metabolite Factory

R Yu, J Liu, Y Wang, H Wang, H Zhang - Frontiers in Chemistry, 2021 - frontiersin.org
Aspergillus niger, one of the most common and important fungal species, is ubiquitous in
various environments. A. niger isolates possess a large number of cryptic biosynthetic gene …

Exploiting endophytic microbes as micro-factories for plant secondary metabolite production

S Mishra, PK Sahu, V Agarwal, N Singh - Applied Microbiology and …, 2021 - Springer
Plant secondary metabolites have significant potential applications in a wide range of
pharmaceutical, food, and cosmetic industries by providing new chemistries and …

[HTML][HTML] Deciphering the role of endophytic microbiome in postharvest diseases management of fruits: Opportunity areas in commercial up-scale production

M Kumari, KA Qureshi, M Jaremko, J White… - Frontiers in Plant …, 2022 - frontiersin.org
As endophytes are widely distributed in the plant's internal compartments and despite
having enormous potential as a biocontrol agent against postharvest diseases of fruits, the …

Methylene-bridged dimeric natural products involving one-carbon unit in biosynthesis

Y Fan, J Shen, Z Liu, K Xia, W Zhu, P Fu - Natural Product Reports, 2022 - pubs.rsc.org
Covering: up to February 2022 Naturally occurring dimeric molecules attract considerable
attention from both chemists and biologists. The methylene-bridged dimers with one-carbon …

OSMAC Strategy: A promising way to explore microbial cyclic peptides

Y Zhang, L Feng, X Hemu, NH Tan, Z Wang - European Journal of …, 2024 - Elsevier
Microbial secondary metabolites are pivotal for the development of novel drugs. However,
conventional culture techniques, have left a vast array of unexpressed biosynthetic gene …

Using next-generation sequencing technology to explore genetic pathways in endophytic fungi in the syntheses of plant bioactive metabolites

M Bielecka, B Pencakowski, R Nicoletti - Agriculture, 2022 - mdpi.com
Recent investigations carried out all over the world have disclosed the capacity of a
multitude of endophytic fungal species/strains to produce bioactive compounds which are …

Physiological and metabolic traits of Taxol biosynthesis of endophytic fungi inhabiting plants: plant-microbial crosstalk, and epigenetic regulators

NZ Mohamed, L Shaban, S Safan… - Microbiological Research, 2023 - Elsevier
Attenuating the Taxol productivity of fungi with the subculturing and storage under axenic
conditions is the challenge that halts the feasibility of fungi to be an industrial platform for …