Abstract Purpose First detected in China in 2019, the novel coronavirus disease (COVID-19)
has rapidly spread globally. Since then, healthcare systems are exposed to major …

Acute hypoxemic respiratory failure is the principal cause of hospitalization, invasive
mechanical ventilation and death in severe COVID-19 infection. Nearly half of intubated …

Background The COVID-19 pandemic has affected the world extraordinarily. This disease
has a potential to cause a significantly severe course of disease leading to respiratory …

Purpose The benefits of antiviral treatment with remdesivir in hospitalized patients with
COVID-19 remain controversial. Clinical analyses are needed to demonstrate which patient …

Aims Patients with cardiac disease are considered high risk for poor outcomes following
hospitalization with COVID-19. The primary aim of this study was to evaluate heterogeneity …

Objectives Remdesivir (RDV) is the cornerstone for treating coronavirus disease 2019
(COVID-19). The active metabolite of RDV, GS-441524 (a nucleoside analogue), has high …

Background Neutrophil serine proteases are involved in the pathogenesis of COVID-19 and
increased serine protease activity has been reported in severe and fatal infection. We …

Acute respiratory distress syndrome (ARDS), a fatal critical disease, is induced by various
insults. ARDS represents a major global public health burden, and the management of …

Background The coronavirus disease 2019 (COVID-19) becomes a worldwide public health
threat. Increasing evidence proves that COVID-19-induced acute injuries could be reversed …

Introduction The coronavirus disease 2019 (COVID-19) pandemic has put a strain on global
healthcare systems. Despite admirable efforts to develop rapidly new pharmacotherapies …