Epithelial cells secrete chloride to regulate water release at mucosal barriers, supporting
both homeostatic hydration and the" weep" response that is critical for type 2 immune …

In mammalian taste buds, Type I cells comprise half of all cells. These are termed “glial-like”
based on morphologic and molecular features, but there are limited studies describing their …

Overcoming refractory epilepsy's resistance to the combination of antiepileptic drugs (AED),
mitigating side effects, and preventing sudden unexpected death in epilepsy are critical …

Taste buds comprise four types of taste cells: three mature, elongate types, Types I–III; and
basally situated, immature postmitotic type, Type IV cells. We employed serial blockface …

The cephalic phase insulin response (CPIR) is classically defined as a head receptor-
induced early release of insulin during eating that precedes a postabsorptive rise in blood …

Bitter and sweet taste G protein-coupled receptors (known as T2Rs and T1Rs, respectively)
were originally identified in type II taste cells on the tongue, where they signal perception of …

ATP is well established as a transmitter and modulator in the peripheral and central nervous
system. While conventional exocytotic release of ATP at synapses occurs, this transmitter is …

Taste is one of our five primary senses, along with smell, sight, hearing, and touch. The
ability to taste is of utmost importance to our well-being and survival; tasting has historically …

Taste buds contain multiple cell types, two of which mediate transduction of specific taste
qualities: Type III cells transduce sour while Type II cells transduce either sweet, or bitter or …

Taste buds are the sensory end organs for gustation, mediating sensations of salty, sour,
bitter, sweet and umami as well as other possible modalities, for example, fat and kokumi …