Highlights•Neurotrophins have been linked to several disorders, including AD and
depression.•Complex biology has led to difficulties in identifying suitable drug …

Cell-based therapy is emerging as a promising strategy for treating a wide range of human
diseases, such as diabetes, blood disorders, acute liver failure, spinal cord injury, and …

The widespread clinical implementation of gene therapy requires the ability to stably
integrate genetic information through gene transfer vectors in a safe, effective, and …

In living organisms, naturally evolved sensors that constantly monitor and process
environmental cues trigger corrective actions that enable the organisms to cope with …

Emerging research has re-emphasized the role of the cortical cholinergic system in the
symptomology and progression of Alzheimer's disease (AD). Basal forebrain (BF) …

Environmental enrichment (EE) is an environmental paradigm encompassing sensory,
cognitive, and physical stimulation at a heightened level. Previous studies have reported the …

The promise of cell therapy has been augmented by introducing biomaterials, where
intricate scaffold shapes are fabricated to accommodate the cells within. In this review, we …

Molecular medicine has entered a high-tech age that provides curative treatments of
complex genetic diseases through genetically engineered cellular medicinal products. Their …

Glaucoma, a progressive optic neuropathy characterized by retinal ganglion cell
degeneration and visual field loss, is the leading cause of irreversible blindness worldwide …

Microglia are the sentinels of the brain but a clear understanding of the factors that modulate
their activation in physiological and pathological conditions is still lacking. Here we …