Membrane transporters can be major determinants of the pharmacokinetic, safety and
efficacy profiles of drugs. This presents several key questions for drug development …

Transporters influence the disposition of chemicals within the body by participating in
absorption, distribution, and elimination. Transporters of the solute carrier family (SLC) …

1. P-glycoprotein (P-gp/MDR1), one of the most clinically important transmembrane
transporters in humans, is encoded by the ABCB1/MDR1 gene. Recent insights into the …

Drug transporters are now widely acknowledged as important determinants governing drug
absorption, excretion, and, in many cases, extent of drug entry into target organs. There is …

Drug transporters are recognized as key players in the processes of drug absorption,
distribution, metabolism, and elimination. The localization of uptake and efflux transporters …

The development of resistance to variety of chemotherapeutic agents is one of the major
challenges in effective cancer treatment. Tumor cells are able to generate a multi-drug …

Advances in genomic technologies have led to a wealth of information identifying genetic
polymorphisms in membrane transporters, specifically how these polymorphisms affect drug …

In vitro data on the metabolism of the antifungal voriconazole suggest that its
pharmacokinetics might be influenced by the activity of CYP2C19, CYP2C9, and CYP3A. To …

Introduction Dabigatran etexilate is given in fixed doses without coagulation monitoring for
the prevention of blood clots in at risk adults. A high inter-individual variability in blood …

Multi-drug resistant (MDR) cancer is a significant clinical obstacle and is often implicated in
cases of recurrent, nonresponsive disease. Targeted nanoparticles were made by …