In the last two decades, the study of the renin–angiotensin–aldosterone system (RAAS) has
revealed a counterregulatory protective axis. This protective arm is characterized by …

Sarcopenia is a condition characterized by a loss of muscle mass and function. In chronic
kidney disease (CKD), where a chronic catabolic state exists, sarcopenia commonly occurs …

Introduction: The receptor for advanced glycation end products (RAGE) and its ligands, such
as high-mobility group protein box 1 (HMGB1), play an important role in the accumulation of …

Fabry disease is a rare X-linked disease characterized by deficient expression and activity of
alpha-galactosidase A (α-GalA) with consequent lysosomal accumulation of …

Cardiovascular-related complications (CVCs) are the primary cause of death in patients
undergoing hemodialysis (HD), accounting for greater than half of all deaths. Beyond …

Two human genetic tubulopathies, Bartter's (BS) and Gitelman's (GS) syndromes, have
normo/hypotension and absent cardiac remodeling despite their apparent angiotensin …

Hypertension and potassium imbalance are commonly observed in chronic kidney disease
(CKD) patients. The development of hypertension would be related to several mechanisms …

Context Limited evidence exists regarding the cumulative dosing and duration impact of
renin-angiotensin system inhibitors (RASi) on cardiorenal and mortality outcomes in patients …

Fabry disease is a rare X-linked disease characterized by deficient expression and activity of
alpha-galactosidase A with consequent lysosomal accumulation of glycosphingolipids …

Background and aims High coronary artery calcification (CAC) burden is a significant risk
factor for adverse cardiovascular and kidney outcomes. However, it is unknown whether …