Neurons are highly susceptible to DNA damage accumulation due to their large energy
requirements, elevated transcriptional activity, and long lifespan. While newer research has …

Biological sex is a factor in many conditions, including aging, neurodegenerative disease,
cancer, and more. For each of these, men and women display distinct differences in disease …

Microglia, the innate immune cells of the brain, influence Alzheimer's disease (AD)
progression and are potential therapeutic targets. However, microglia exhibit diverse …

Defective DNA damage signalling and repair is a hallmark of age-related and genetic
neurodegenerative disease. One mechanism implicated in disease progression is DNA …

The cGAS-STING (cyclic GMP–AMP synthase (cGAS)–stimulator of interferon genes
(STING)) axis integrates DNA damage and cellular stress with type I interferon (IFN) …

DNA damage and neurodegenerative disorders are intimately linked but the underlying
mechanism remains elusive. Here, we show that persistent DNA lesions in tissue-resident …

In brain, the striatum is a heterogenous region involved in reward and goal-directed
behaviors. Striatal dysfunction is linked to psychiatric disorders, including opioid use …

Aging is a complex and inevitable biological process affected by a combination of external
environmental and genetic factors. Humans are currently living longer than ever before …

After brain injury, infiltration and abnormal activation of neutrophils damages brain tissue
and worsens inflammation, but the mediators that connect activated neutrophils with …

Neurodegenerative disorders are primarily characterized by neuron loss progressively
leading to cognitive decline and the manifestation of incurable and debilitating conditions …