The Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling
pathway was discovered more than a quarter-century ago. As a fulcrum of many vital cellular …

Psoriasis is a chronic inflammatory disease characterised by sharply demarcated
erythematous and scaly skin lesions accompanied by systemic manifestations. Classified by …

Background and Aims The impact of Coronavirus disease 2019 (COVID-19) on patients with
inflammatory bowel disease (IBD) is unknown. We sought to characterize the clinical course …

An enhanced understanding of the importance of Janus kinase (JAK) and signal transducer
and activator of transcription (STAT) signalling in multiple disease states has led to an …

Cytokines are involved in intestinal homeostasis and pathological processes associated
with inflammatory bowel disease (IBD). The biological effects of cytokines, including several …

Inflammatory bowel diseases (IBD) such as ulcerative colitis and Crohn's disease are
chronic, relapsing and remitting disorders of intestinal inflammation with potential systemic …

Accumulating data on cellular and molecular pathways help to develop novel therapeutic
strategies in skin inflammation and autoimmunity. Examples are psoriasis and atopic …

As a main digestive organ and an important immune organ, the intestine plays a vital role in
resisting the invasion of potential pathogens into the body. Intestinal immune dysfunction …

Autoimmune and inflammatory diseases are common and diverse, and they can affect
nearly any organ system. Much of the pathogenesis of these diseases is related to …

In ulcerative colitis, treating beyond endoscopic healing has shown a reduction of relapse
and hospitalization, pushing for histological remission to be embraced in clinical practice …