Molecular markers guiding thyroid cancer management

C Nylén, R Mechera, I Maréchal-Ross, V Tsang… - Cancers, 2020 - mdpi.com
The incidence of thyroid cancer is rapidly increasing, mostly due to the overdiagnosis and
overtreatment of differentiated thyroid cancer (TC). The increasing use of potent preclinical …

The neurotransmitter calcitonin gene-related peptide shapes an immunosuppressive microenvironment in medullary thyroid cancer

Y Hou, B Lin, T Xu, J Jiang, S Luo, W Chen… - Nature …, 2024 - nature.com
Neurotransmitters are key modulators in neuro-immune circuits and have been linked to
tumor progression. Medullary thyroid cancer (MTC), an aggressive neuroendocrine tumor …

Management of differentiated thyroid cancer: The standard of care

AM Avram, K Zukotynski, HR Nadel… - Journal of nuclear …, 2022 - Soc Nuclear Med
In the past decade, the management of differentiated thyroid cancer (DTC) underwent a
paradigm shift toward the use of risk stratification with the goal of maximizing the benefit and …

Efficacy and safety of thermal ablation for solitary T1bN0M0 papillary thyroid carcinoma: a multicenter study

XJ Cao, J Liu, YL Zhu, L Qi, G Liu… - The Journal of …, 2021 - academic.oup.com
Background Ultrasound-guided thermal ablation plays an important role in the management
of thyroid disease. The objective of this study was to evaluate the feasibility, efficacy, and …

Thyroid cancer in the age of COVID-19

VHM Tsang, M Gild, A Glover… - Endocrine-Related …, 2020 - erc.bioscientifica.com
COVID-19 has modified the way we practice medicine. For thyroid cancer, there have been
several significant impacts. First, the diagnosis has been delayed due to social isolation …

The translational values of TRIM family in pan-cancers: From functions and mechanisms to clinics

G Zhao, C Liu, X Wen, G Luan, L Xie, X Guo - Pharmacology & …, 2021 - Elsevier
Cancer is the second leading cause of human death across the world. Tripartite motif (TRIM)
family, with E3 ubiquitin ligase activities in majority of its members, is reported to be involved …

circRAPGEF5 contributes to papillary thyroid proliferation and metastatis by regulation miR-198/FGFR1

W Liu, J Zhao, M Jin, M Zhou - Molecular Therapy-Nucleic Acids, 2019 - cell.com
The circular RNA RAPGEF5 (circRAPGEF5) is generated from five exons of the RAPGEF5
gene and abnormal expression in papillary thyroid cancer (PTC). However, whether …

Mutational profiling of poorly differentiated and anaplastic thyroid carcinoma by the use of targeted next‐generation sequencing

H Duan, Y Li, P Hu, J Gao, J Ying, W Xu… - …, 2019 - Wiley Online Library
Aims To characterise the mutational profiles of poorly differentiated thyroid carcinoma
(PDTC) and anaplastic thyroid carcinoma (ATC) and to identify markers with potential …

Glycosylation in the thyroid gland: vital aspects of glycoprotein function in thyrocyte physiology and thyroid disorders

M Ząbczyńska, K Kozłowska, E Pocheć - International journal of …, 2018 - mdpi.com
The key proteins responsible for hormone synthesis in the thyroid are glycosylated.
Oligosaccharides strongly affect the function of glycosylated proteins. Both thyroid …

Oxidative stress and radioiodine treatment of differentiated thyroid cancer

A Buczyńska, I Sidorkiewicz, M Rogucki, K Siewko… - Scientific reports, 2021 - nature.com
It is hypothesized that the oxidative stress level in thyroid cancer patients is additionally
upregulated by radioactive iodine (RAI) treatment, that may exert an important impact on …