[HTML][HTML] Fungal secondary metabolites as inhibitors of the ubiquitin–proteasome system
M Staszczak - International Journal of Molecular Sciences, 2021 - mdpi.com
The ubiquitin–proteasome system (UPS) is the major non-lysosomal pathway responsible
for regulated degradation of intracellular proteins in eukaryotes. As the principal proteolytic …
for regulated degradation of intracellular proteins in eukaryotes. As the principal proteolytic …
Morelloflavone as Phytomedicine-An Ethnopharmacological Review on the Therapeutical Properties, Biological Efficacy and Pharmacological Activity
DK Patel - Anti-Infective Agents, 2023 - ingentaconnect.com
Background: Flavonoids are low molecular weight class secondary metabolites found to be
present throughout the plant kingdom. Structurally, flavonoid class phytochemicals consist of …
present throughout the plant kingdom. Structurally, flavonoid class phytochemicals consist of …
Total Synthesis of the 2, 5-Disubstituted γ-Pyrone E1 UAE Inhibitor Himeic Acid A
H Lu, KL Handore, TE Wood, GK Shimokura… - Organic …, 2023 - ACS Publications
The first total synthesis of the E1 ubiquitin-activating enzyme inhibitor, himeic acid A, is
reported. A McCombie reaction was used to form the core γ-pyrone via a 6π …
reported. A McCombie reaction was used to form the core γ-pyrone via a 6π …
Nature of Irreversible Inhibition of Human 20S Proteasome by Salinosporamide A. The Critical Role of Lys–Asp Dyad Revealed from Electrostatic Effects Analysis
20S proteasome is the enzymatic core engine involved in the processes of cellular protein
regulation, thus becoming a promising target inter alia in the therapy of many diseases. In …
regulation, thus becoming a promising target inter alia in the therapy of many diseases. In …
On the Origin of the Different Reversible Characters of Salinosporamide A and Homosalinosporamide A in the Covalent Inhibition of the Human 20S Proteasome
Covalent inhibition of the 20S proteasome is one of the strategies used in the fight against
cancer, Chagas' disease, malaria, tuberculosis, or neurodegenerative disorders. In this …
cancer, Chagas' disease, malaria, tuberculosis, or neurodegenerative disorders. In this …
The literature of heterocyclic chemistry, Part XIX, 2019
LI Belen'kii, GA Gazieva, YB Evdokimenkova… - Advances in …, 2022 - Elsevier
A systematized survey of reviews and monographs published in 2019 on all aspects of
heterocyclic chemistry is given. Methods for the synthesis, reactivity, and practically useful …
heterocyclic chemistry is given. Methods for the synthesis, reactivity, and practically useful …
Synthesis and Evaluation of 5-Substituted (Thio) barbiturates as Proteasome Inhibitors dor Cancer Therapy
S Hummeid - 2019 - search.proquest.com
O presente relatório de estágio foi elaborado com o objectivo de obter o grau de Mestre em
Ciências Farmacêuticas. Encontra-se subdividida em três capítulos que abordam cada um …
Ciências Farmacêuticas. Encontra-se subdividida em três capítulos que abordam cada um …