The role of Mfsd2a in nervous system diseases

B Huang, X Li - Frontiers in Neuroscience, 2021 - frontiersin.org
Major facilitator superfamily (MFS) is the maximum and most diversified membrane
transporter, acting as uniporters, symporters and antiporters. MFS is considered to have a …

The role of lipids in the central nervous system and their pathological implications in amyotrophic lateral sclerosis

TJ Tracey, SE Kirk, FJ Steyn, ST Ngo - Seminars in Cell & Developmental …, 2021 - Elsevier
Lipids play an important role in the central nervous system (CNS). They contribute to the
structural integrity and physical characteristics of cell and organelle membranes, act as …

A unique inflammation-related mechanism by which high-fat diets induce depression-like behaviors in mice

H Yu, B Yu, X Qin, W Shan - Journal of affective disorders, 2023 - Elsevier
Background High-fat diet (HFD) consumption is an important reason for promoting
depression, but the mechanism is unclear. The present study aims to explore the …

GSDMD knockdown attenuates phagocytic activity of microglia and exacerbates seizure susceptibility in TLE mice

X Yang, Q Cao, Y Guo, J He, D Xu, A Lin - Journal of Neuroinflammation, 2023 - Springer
Background Temporal lobe epilepsy (TLE) is often characterized pathologically by severe
neuronal loss in the hippocampus. Phagocytic activity of microglia is essential for clearing …

Peripheral cytokine and fatty acid associations with neuroinflammation in AD and aMCI patients: An exploratory study

G Cisbani, A Koppel, D Knezevic, I Suridjan… - Brain, Behavior, and …, 2020 - Elsevier
Neuroinflammation is thought to be important in the progression of Alzheimer's disease
(AD). To evaluate cerebral inflammation radioligands that target TSPO, a translocator protein …

Exploring the Metabolic Effects of a Herbal Remedy of Asarum sieboldii, Platycodon grandiflorum, and Cinnamomum cassia Extracts: Unraveling Its Therapeutic …

G Lee, BH Jung, T Lee, JH Park, HS Kim, H Kim… - Antioxidants, 2024 - mdpi.com
Our previous study demonstrated that our novel herbal remedy, a mixture of Asarum
sieboldii, Platycodon grandiflorum, and Cinnamomum Cassia extracts, exhibits a therapeutic …

The association between polyunsaturated fatty acids and periodontitis: NHANES 2011–2014 and Mendelian randomisation analysis

T Li, H Wu, Z Fu, H Li, Q Li, Y Liu, Q Zhang - Lipids in Health and Disease, 2024 - Springer
Background We aimed to explore the association and potential causality between
polyunsaturated fatty acids concentrations and the risk of periodontal disease. Materials and …

Monounsaturated and polyunsaturated fatty acids: structure, food sources, biological functions, and their preventive role against noncommunicable diseases

MÁ Rincón-Cervera, R Bravo-Sagua… - … food components activity …, 2022 - Elsevier
Polyunsaturated and monounsaturated fatty acids, respectively known as PUFA and MUFA,
are considered bioactive compounds. Nuts and seeds, fish, and other marine products are …

Metabolic profiling reveals an abnormal pattern of serum fatty acids in MRL/lpr mice under treatment with prednisone

Q Li, J Zhou, D Zhang, X Zhang, Z Xu… - Frontiers in …, 2020 - frontiersin.org
Glucocorticoids (GCs) are commonly used to treat systemic lupus erythematosus (SLE).
Unfortunately, excessive GCs can induce many side effects associated with disordered fatty …

Effects of distinct n-6 to n-3 polyunsaturated fatty acid ratios on insulin resistant and AD-like phenotypes in high-fat diets-fed APP/PS1 mice

X Ma, Y Guo, J Xu, X Wang, S Dong, Y Gao… - Food Research …, 2022 - Elsevier
Type 2 diabetes mellitus (T2DM) and Alzheimer's disease (AD) are prevalent diseases with
similar pathophysiological characteristics and genetic predispositions. Polyunsaturated fatty …