This year marks the tenth anniversary of cell therapy with chimeric antigen receptor (CAR)-
modified T cells for refractory leukemia. The widespread commercial approval of genetically …

The success of targeted therapies and immunotherapies has created optimism that cancers
may be curable. However, not all patients respond, drug resistance is common and many …

The bone marrow constitutes the primary site for life-long blood production and skeletal
regeneration. However, its cellular and spatial organization remains controversial. Here, we …

The bone marrow microenvironment has a key role in regulating haematopoiesis, but its
molecular complexity and response to stress are incompletely understood. Here we map the …

Aging is a multifaceted and complicated process, manifested by a decline of normal
physiological functions across tissues and organs, leading to overt frailty, mortality, and …

The haematopoietic stem cell (HSC) microenvironment in the bone marrow, termed the
niche, ensures haematopoietic homeostasis by controlling the proliferation, self-renewal …

Haematopoietic stem and progenitor cell (HSPC) gene therapy has emerged as an effective
treatment modality for monogenic disorders of the blood system such as primary …

Structured models of ontogenic, phenotypic and functional diversity have been instrumental
for a renewed understanding of the biology of immune cells, such as macrophages and …

Mortality among patients with chronic kidney disease (CKD) is largely a consequence of
cardiovascular disease (CVD) and is a particular concern given the increasing prevalence of …

Recent advances have highlighted the ability of hematopoietic stem and progenitor cells in
the bone marrow to sense peripheral inflammation or infection and adapt through increased …