Precision medicine in non-small cell lung cancer: Current applications and future directions
Advances in biomarkers, targeted therapies, and immuno-oncology have transformed the
clinical management of patients with advanced NSCLC. For oncogene-driven tumors, there …
clinical management of patients with advanced NSCLC. For oncogene-driven tumors, there …
MET-dependent solid tumours—molecular diagnosis and targeted therapy
Attempts to develop MET-targeted therapies have historically focused on MET-expressing
cancers, with limited success. Thus, MET expression in the absence of a genomic marker of …
cancers, with limited success. Thus, MET expression in the absence of a genomic marker of …
Amivantamab plus lazertinib in osimertinib-relapsed EGFR-mutant advanced non-small cell lung cancer: a phase 1 trial
Patients with epidermal growth factor receptor (EGFR)-mutated non-small cell lung cancer
(NSCLC) often develop resistance to current standard third-generation EGFR tyrosine …
(NSCLC) often develop resistance to current standard third-generation EGFR tyrosine …
[HTML][HTML] MET exon 14 skipping mutations in non–small-cell lung cancer: an overview of biology, clinical outcomes, and testing considerations
MA Socinski, NA Pennell, KD Davies - JCO precision oncology, 2021 - ncbi.nlm.nih.gov
In the United States, lung cancer is the second most frequently diagnosed type of cancer
and the leading cause of cancer deaths. 1 Non–small-cell lung cancer (NSCLC), which …
and the leading cause of cancer deaths. 1 Non–small-cell lung cancer (NSCLC), which …
MET alterations in NSCLC—current perspectives and future challenges
J Remon, LEL Hendriks, G Mountzios… - Journal of Thoracic …, 2023 - Elsevier
Targeted therapies have revolutionized the treatment and improved the outcome for
oncogene-driven NSCLC and an increasing number of oncogenic driver therapies have …
oncogene-driven NSCLC and an increasing number of oncogenic driver therapies have …
Targeting MET Dysregulation in Cancer
Aberrant MET signaling can drive tumorigenesis in several cancer types through a variety of
molecular mechanisms including MET gene amplification, mutation, rearrangement, and …
molecular mechanisms including MET gene amplification, mutation, rearrangement, and …
[HTML][HTML] Crizotinib in c-MET-or ROS1-positive NSCLC: results of the AcSé phase II trial
D Moro-Sibilot, N Cozic, M Pérol, J Mazières, J Otto… - Annals of oncology, 2019 - Elsevier
Abstract Background In 2013, the French National Cancer Institute initiated the AcSé
program to provide patients with secure access to targeted therapies outside of their …
program to provide patients with secure access to targeted therapies outside of their …
Targeted therapy in advanced and metastatic non-small cell lung cancer. An update on treatment of the most important actionable oncogenic driver alterations
D Koenig, S Savic Prince, SI Rothschild - Cancers, 2021 - mdpi.com
Simple Summary The treatment of advanced and metastatic non-small cell lung cancer
(NSCLC) has changed dramatically in recent years due to advanced molecular diagnostics …
(NSCLC) has changed dramatically in recent years due to advanced molecular diagnostics …
[HTML][HTML] Bio-inspired, bio-degradable adenosine 5′-diphosphate-modified hyaluronic acid coordinated hydrophobic undecanal-modified chitosan for hemostasis and …
Y Liu, H Niu, C Wang, X Yang, W Li, Y Zhang, X Ma… - Bioactive Materials, 2022 - Elsevier
Uncontrolled hemorrhage and wound infection are crucial causes of trauma-associated
death in both the military and the clinic. Therefore, developing an efficient and rapid …
death in both the military and the clinic. Therefore, developing an efficient and rapid …
[HTML][HTML] Identification of the active compounds and functional mechanisms of Jinshui Huanxian formula in pulmonary fibrosis by integrating serum pharmacochemistry …
D Shao, X Liu, J Wu, A Zhang, Y Bai, P Zhao, J Li - Phytomedicine, 2022 - Elsevier
Abstract Background Jinshui Huanxian formula (JHF), a traditional Chinese medicine (TCM),
has been demonstrated to attenuate idiopathic pulmonary fibrosis (IPF). The active …
has been demonstrated to attenuate idiopathic pulmonary fibrosis (IPF). The active …