Adenosine triphosphate (ATP) has been well established as an important extracellular
ligand of autocrine signaling, intercellular communication, and neurotransmission with …

Gap junctions and hemichannels comprised of connexins impact many cellular processes.
Significant advances in our understanding of the functional role of these channels have …

Gap junction channels mediate intercellular signalling that is crucial in tissue development,
homeostasis and pathologic states such as cardiac arrhythmias, cancer and trauma. To …

This review is based in part on a roundtable discussion session:“Physiological roles for
heterotypic/heteromeric channels” at the 2013 International Gap Junction Conference (IGJC …

There are now at least 14 distinct diseases linked to germ line mutations in the 21 genes that
encode the connexin (Cx) family of gap junction proteins. This review focuses on the links …

Despite concerted clinical and research efforts, cancer is a leading cause of death
worldwide. Surgery, radiation, and chemotherapy have remained the most common …

Inherited or acquired alterations in the structure and function of connexin proteins have long
been associated with disease. In the present work, we review current knowledge on the role …

Aberrant opening of nonjunctional connexin hemichannels at the plasma membrane is
associated with many diseases, including ischemia and muscular dystrophy. Proper control …

Normal development, function and repair of the sensory epithelia in the inner ear are all
dependent on gap junctional intercellular communication. Mutations in the connexin genes …

Maintenance of constant brain pH is critically important to support the activity of individual
neurons, effective communication within the neuronal circuits, and, thus, efficient processing …