Valid and reliable biomarkers can play an important role in clinical trials as indicators of
biological or pathogenic processes or as a signal of treatment response. Currently, there are …

Advances in pharmacogenomics (PGx) have the potential to transform healthcare by
allowing precision medicine to become a reality. However, PGx knowledge is new, complex …

Purpose Precision pain medicine focuses on employing methods to assess each patient
individually, identify their risk profile for disproportionate pain and/or the development of …

Background Opioids are widely used for chronic low back pain (CLBP); however, it is still
unclear how to predict their effectiveness and safety. Codeine, tramadol and oxycodone are …

Methods: This narrative review describes and evaluates clinical trial phases, specific POC
pain trials, and approaches to patient profiling. Results: We describe common POC trial …

Pain can have a significantly negative impact on the quality of life of patients. Therefore,
patients may resort to analgesics to relieve the pain. The struggle to manage pain in cancer …

Pain is an unpleasant feeling usually resulting from tissue damage that can persist along
weeks, months, or even years after the injury, turning into pathological chronic pain, the …

Purpose Chronic pain is a life changing condition, and non-opioid treatments have been
lately introduced to overcome the addictive nature of opioid therapies and their side effects …

Несмотря на достижения здравоохранения, существующие на сегодняшний день
анальгетики не всегда обладают достаточной специфичностью и эффективностью в …

Background People often state that they are “sensitive” or “insensitive” to pain. However, the
accuracy and clinical relevance of such statements is unclear. Objective The aim of this …