In this review, we comprehensively present the function of epigenetic regulations in normal
placental development as well as in a prominent disease of placental origin, preeclampsia …

Genomic imprinting is widespread in eutherian mammals. Marsupial mammals also have
genomic imprinting, but in fewer loci. It has long been thought that genomic imprinting is …

A fundamental initiative for evolutionary biologists is to understand the molecular basis
underlying phenotypic diversity. A long-standing hypothesis states that species-specific traits …

Background Cytosine DNA methylation is a heritable epigenetic mark present in most
eukaryotic groups. While the patterns and functions of DNA methylation have been …

PEG10 and PEG11/RTL1 are paternally expressed, imprinted genes that play essential
roles in the current eutherian developmental system and are therefore associated with …

In viviparous mammals, genomic imprinting regulates parent-of-origin-specific monoallelic
expression of paternally and maternally expressed imprinted genes (PEGs and MEGs) in a …

Mammalian genomes include many maternally and paternally imprinted genes. Most of
these are also expressed in the brain, and several have been implicated in regulating …

Non-coding RNAs (ncRNAs) are regulatory elements of gene expression and chromatin
structure. Both long and small ncRNAs can also act as inductors and targets of epigenetic …

Theories focused on kinship and the genetic conflict it induces are widely considered to be
the primary explanations for the evolution of genomic imprinting. However, there have …

In mammals successful rearing imposes a cost on later reproductive fitness specifically on
the mother creating the potential for parental conflict. Loss of function of three imprinted …