Its increasing incidence has led stroke to be the second leading cause of death worldwide.
Despite significant advances in recanalization strategies, patients are still at risk for …

Stroke is the second leading cause of death worldwide and a leading cause of disability.
Most strokes are caused by occlusion of a major cerebral artery, and substantial advances …

Background Neuronal pyroptosis and neuroinflammation with excess microglial activation
are widely involved in the early pathological process of ischemic stroke. Repetitive …

Blood-Brain Barrier (BBB) disruption is an important pathophysiological process of acute
ischemic stroke (AIS), resulting in devastating malignant brain edema and hemorrhagic …

Ischemic stroke, which accounts for 75–80% of all strokes, is the predominant cause of
morbidity and mortality worldwide. The post-stroke immune response has recently emerged …

Background Pyroptosis mediated by NLRP3 inflammasome plays a critical role in the
pathogenesis of cerebral ischemia-reperfusion (I/R) injury. Mounting evidences have …

Ischemic stroke is a leading cause of morbidity and mortality worldwide. Resident microglia
are the principal immune cells of the brain, and the first to respond to the pathophysiological …

Inflammation is currently considered a prime target for the development of new stroke
therapies. In the acute phase of ischemic stroke, microglia are activated and then circulating …

There is a growing interest in using natural medicines to treat stroke as the leading cause of
disability worldwide. Especially plant-derived natural medicines have multiple beneficial …

Microglia/macrophages are the major immune cells involved in the defence against brain
damage. Their morphology and functional changes are correlated with the release of danger …