Atomic force microscopy (AFM) has made significant contributions to the study of protein-
DNA interactions by making it possible to topographically image biological samples. A …

DNA damage repair starts with the recognition of damaged sites from predominantly normal
DNA. In eukaryotes, diverse DNA lesions from environmental sources are recognized by the …

Rad4/XPC recognizes diverse DNA lesions including ultraviolet-photolesions and
carcinogen-DNA adducts, initiating nucleotide excision repair. Studies have suggested that …

The ultraviolet (UV) radiation-induced DNA lesions play a causal role in many prevalent
genetic skin-related diseases and cancers. The damage sensing protein Rad4/XPC …

The dynamics and mechanism of how site-specific DNA-bending proteins initially interrogate
potential binding sites prior to recognition have remained elusive for most systems. Here we …

How DNA-bending proteins recognize their specific sites on DNA remains elusive,
particularly for proteins that use indirect readout, which relies on sequence-dependent …

Altered unwinding/bending fluctuations at DNA lesion sites are implicated as plausible
mechanisms for damage sensing by DNA-repair proteins. These dynamics are expected to …

Genome integrity is seriously threatened by UV radiation's ability to cause damage in DNA.
CPD and 6-4PP are two of the most frequent lesions brought on by Ultraviolet radiation …

How DNA-binding proteins search for and identify their target sites buried amid a vast
excess of non-target sites remains a central question in biology. This study is aimed at …

Integration host factor (IHF) is a small hetero dimeric protein (~ 20 kDa), ubiquitous in
eubacteria. It binds to DNA in a sequence-specific manner and causes~ 35-bp long cognate …