Achieving sufficient delivery across the blood–brain barrier is a key challenge in the
development of drugs to treat central nervous system (CNS) disorders. This is particularly …

Nanoparticles (NPs) have attracted considerable attention in various fields, such as
cosmetics, the food industry, material design, and nanomedicine. In particular, the fast …

In today's modern era of medicine, macromolecular compounds such as proteins, peptides
and nucleic acids are dethroning small molecules as leading therapeutics. Given their …

The inert nature of most commercial polymers and nanomaterials results in limitations of
applications in various industrial fields. This can be solved by surface modifications to …

Central nervous system diseases are a heavy burden on society and health care systems.
Hence, the delivery of drugs to the brain has gained more and more interest. The brain is …

Conventional chemotherapy lacking target selectivity often leads to severe side effects,
limiting the effectiveness of chemotherapy. Therefore, drug delivery systems ensuring both …

Short interfering RNAs (siRNA) are a powerful class of genetic medicines whose clinical
translation can be hindered by their suboptimal delivery properties in vivo. Here, we provide …

As nanocarriers (NCs) can improve the solubility of drugs, prevent their degradation by
gastrointestinal (GI) enzymes and promote their transport across the mucus gel layer and …

Based on their tunable physicochemical properties and the possibility of producing cell-
specific platforms through surface modification with functional biomolecules, nanoparticles …

Cell-penetrating peptides (CPPs) are naturally able to cross the lipid bilayer membrane that
protects cells. These peptides share common structural and physicochemical properties and …