Autophagy, ferroptosis, pyroptosis, and necroptosis in tumor immunotherapy
W Gao, X Wang, Y Zhou, X Wang, Y Yu - Signal transduction and …, 2022 - nature.com
In recent years, immunotherapy represented by immune checkpoint inhibitors (ICIs) has led
to unprecedented breakthroughs in cancer treatment. However, the fact that many tumors …
to unprecedented breakthroughs in cancer treatment. However, the fact that many tumors …
Immunogenic cell stress and death
Dying mammalian cells emit numerous signals that interact with the host to dictate the
immunological correlates of cellular stress and death. In the absence of reactive antigenic …
immunological correlates of cellular stress and death. In the absence of reactive antigenic …
Copper induces cell death by targeting lipoylated TCA cycle proteins
Copper is an essential cofactor for all organisms, and yet it becomes toxic if concentrations
exceed a threshold maintained by evolutionarily conserved homeostatic mechanisms. How …
exceed a threshold maintained by evolutionarily conserved homeostatic mechanisms. How …
Apoptotic cell death in disease—Current understanding of the NCCD 2023
I Vitale, F Pietrocola, E Guilbaud… - Cell Death & …, 2023 - nature.com
Apoptosis is a form of regulated cell death (RCD) that involves proteases of the caspase
family. Pharmacological and genetic strategies that experimentally inhibit or delay apoptosis …
family. Pharmacological and genetic strategies that experimentally inhibit or delay apoptosis …
Mitochondria and cell death-associated inflammation
E Vringer, SWG Tait - Cell Death & Differentiation, 2023 - nature.com
Mitochondria have recently emerged as key drivers of inflammation associated with cell
death. Many of the pro-inflammatory pathways activated during cell death occur upon …
death. Many of the pro-inflammatory pathways activated during cell death occur upon …
Oncolytic virotherapy: basic principles, recent advances and future directions
D Lin, Y Shen, T Liang - Signal transduction and targeted therapy, 2023 - nature.com
Oncolytic viruses (OVs) have attracted growing awareness in the twenty-first century, as they
are generally considered to have direct oncolysis and cancer immune effects. With the …
are generally considered to have direct oncolysis and cancer immune effects. With the …
Pore-forming proteins as drivers of membrane permeabilization in cell death pathways
P Vandenabeele, G Bultynck… - Nature Reviews Molecular …, 2023 - nature.com
Regulated cell death (RCD) relies on activation and recruitment of pore-forming proteins
(PFPs) that function as executioners of specific cell death pathways: apoptosis regulator …
(PFPs) that function as executioners of specific cell death pathways: apoptosis regulator …
GPX4 in cell death, autophagy, and disease
ABSTRACT Selenoprotein GPX4 (glutathione peroxidase 4), originally known as PHGPX
(phospholipid hydroperoxide glutathione peroxidase), is the main oxidoreductase in the use …
(phospholipid hydroperoxide glutathione peroxidase), is the main oxidoreductase in the use …
Targeting immunogenic cell death in cancer
A Ahmed, SWG Tait - Molecular oncology, 2020 - Wiley Online Library
Immunogenic cell death (ICD) is a type of cancer cell death triggered by certain
chemotherapeutic drugs, oncolytic viruses, physicochemical therapies, photodynamic …
chemotherapeutic drugs, oncolytic viruses, physicochemical therapies, photodynamic …
Ferroptosis: machinery and regulation
Ferroptosis is an iron-dependent, non-apoptotic form of regulated cell death caused by lipid
peroxidation, which is controlled by integrated oxidation and antioxidant systems. The iron …
peroxidation, which is controlled by integrated oxidation and antioxidant systems. The iron …