[HTML][HTML] The role of the immunosuppressive PD-1/PD-L1 checkpoint pathway in the aging process and age-related diseases
A Salminen - Journal of Molecular Medicine, 2024 - Springer
The accumulation of senescent cells within tissues is a hallmark of the aging process.
Senescent cells are also commonly present in many age-related diseases and in the cancer …
Senescent cells are also commonly present in many age-related diseases and in the cancer …
Identification and functional analysis of senescent cells in the cardiovascular system using omics approaches
Cardiovascular disease (CVD) is a leading cause of morbidity and mortality worldwide, and
senescent cells have emerged as key contributors to its pathogenesis. Senescent cells …
senescent cells have emerged as key contributors to its pathogenesis. Senescent cells …
Fibroblast-derived CXCL14 aggravates crystalline silica–induced pulmonary fibrosis by mediating polarization and recruitment of interstitial macrophages
Exposure to crystalline silica (CS) particles in worksites and dwellings can lead to silicosis
due to excessive fibroblast activation. Considering their immuno-regulatory activities, the …
due to excessive fibroblast activation. Considering their immuno-regulatory activities, the …
[HTML][HTML] Cellular senescence of renal tubular epithelial cells in acute kidney injury
J Chen, H Zhang, X Yi, Q Dou, X Yang, Y He… - Cell Death …, 2024 - nature.com
Cellular senescence represents an irreversible state of cell-cycle arrest during which cells
secrete senescence-associated secretory phenotypes, including inflammatory factors and …
secrete senescence-associated secretory phenotypes, including inflammatory factors and …
[HTML][HTML] The binding of HSPA8 and mitochondrial ALDH2 mediates oxygen-glucose deprivation-induced fibroblast senescence
W Hui, T Song, L Yu, X Chen - Antioxidants, 2023 - mdpi.com
Cellular senescence refers to the permanent and irreversible cessation of the cell cycle.
Recently, it has gained significant interest as a promising target for preventing …
Recently, it has gained significant interest as a promising target for preventing …
[HTML][HTML] Targeting tumor suppressor p53 for organ fibrosis therapy
YN Bao, Q Yang, XL Shen, WK Yu, L Zhou… - Cell Death & …, 2024 - nature.com
Fibrosis is a reparative and progressive process characterized by abnormal extracellular
matrix deposition, contributing to organ dysfunction in chronic diseases. The tumor …
matrix deposition, contributing to organ dysfunction in chronic diseases. The tumor …
Senescence and tissue fibrosis: opportunities for therapeutic targeting
Cellular senescence is a key hallmark of aging. It has now emerged as a key mediator in
normal tissue turnover and is associated with a variety of age-related diseases, including …
normal tissue turnover and is associated with a variety of age-related diseases, including …
Lens capsule advanced glycation end products induce senescence in epithelial cells: Implications for secondary cataracts
G Cooksley, MH Nam, RB Nahomi, J Rankenberg… - Aging …, 2024 - Wiley Online Library
Posterior capsule opacification (PCO) is a common complication after cataract surgery.
Residual lens epithelial cells (LECs) on the anterior lens capsule, after cataract surgery …
Residual lens epithelial cells (LECs) on the anterior lens capsule, after cataract surgery …
[HTML][HTML] Inhibitory immune checkpoints suppress the surveillance of senescent cells promoting their accumulation with aging and in age-related diseases
A Salminen - Biogerontology, 2024 - Springer
The accumulation of pro-inflammatory senescent cells within tissues is a common hallmark
of the aging process and many age-related diseases. This modification has been called the …
of the aging process and many age-related diseases. This modification has been called the …
[HTML][HTML] The impact of aging on cardiac repair and regeneration
I Anwar, X Wang, RE Pratt, VJ Dzau… - Journal of Biological …, 2024 - Elsevier
In contrast to neonates and lower organisms, the adult mammalian heart lacks any capacity
to regenerate following injury. The vast majority of our understanding of cardiac …
to regenerate following injury. The vast majority of our understanding of cardiac …